Percutaneous Revascularization for Ischemic Ventricular Dysfunction: Rationale and Design of the REVIVED-BCIS2 Trial: Percutaneous Coronary Intervention for Ischemic Cardiomyopathy

JACC. Heart Failure
Divaka PereraREVIVED investigators

Abstract

Evaluate whether PCI in combination with optimal medical therapy (OMT) will reduce all-cause death and hospitalization for HF compared to a strategy of OMT alone. Ischemic cardiomyopathy (ICM) is the most common cause of heart failure (HF) and is associated with significant mortality and morbidity. Surgical revascularization has been shown to improve long-term outcomes in some patients, but surgery itself carries a major early hazard. Percutaneous coronary intervention (PCI) may allow a better balance between risk and benefit. REVIVED-BCIS2 is a prospective, multi-center, open-label, randomized controlled trial, funded by the National Institute for Health Research in the United Kingdom. Follow-up will be for at least 2 years from randomization. Secondary outcomes include left ventricular ejection fraction (LVEF), quality of life scores, appropriate implantable cardioverter defibrillator therapy and acute myocardial infarction. Patients with LVEF ≤35%, extensive coronary disease and demonstrable myocardial viability are eligible for inclusion and those with a myocardial infarction within 4 weeks, decompensated HF or sustained ventricular arrhythmias within 72 h are excluded. A trial of 700 patients has more than 85% power to det...Continue Reading

Citations

Feb 20, 2019·European Heart Journal·John G F ClelandPiotr Ponikowski
Aug 5, 2020·JAMA : the Journal of the American Medical Association·Sean P MurphyJames L Januzzi
Feb 8, 2019·Current Treatment Options in Cardiovascular Medicine·Youssef RahbanNavin K Kapur
Jul 8, 2020·BMC Cardiovascular Disorders·Haiming DangYong Zeng
Oct 18, 2020·Nature Reviews. Cardiology·Prakriti GabaGregg W Stone
Jan 14, 2021·Heart·Matthew RyanDivaka Perera
Jun 8, 2021·European Heart Journal Cardiovascular Imaging·Ana G AlmeidaUNKNOWN 2018–2020 EACVI President:
Aug 28, 2021·European Heart Journal·Theresa A McDonaghUNKNOWN ESC Scientific Document Group
Oct 12, 2021·European Heart Journal·Raffaele De CaterinaWilliam E Boden

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