[Percutaneous transluminal angioplasty for experimental carotid artery stenosis. Mechanism and long-term results].

Neurologia Medico-chirurgica
E Maemura

Abstract

Percutaneous transluminal angioplasty (PTA) is not commonly applied to the carotid artery because of the risk of cerebral embolization and the uncertainty concerning the long-term results. To test its effectiveness and safety, the author performed PTA in dogs with experimentally induced carotid artery stenosis. Under general anesthesia, one carotid artery was exposed by midline incision. Two vascular tourniquets were applied to the artery, 2 to 5 cm apart, and the blood between them was replaced with pentobarbital sodium for 5 minutes. The drug was then removed and the tourniquets released. Angiography revealed the formation of stenotic lesions within 1 to 6 weeks. Histological examination showed the source of stenosis to be thrombi adhering to the vessel wall. PTA was performed 1 week or 3 to 6 weeks after induction of stenosis using either Grüntzig or Dotter catheters. Immediately after PTA, considerable enlargement of stenotic areas was angiographically observed, and no emboli were detected in distal arteries. Histological findings included depressions in the intima, thrombi, and stretching of the internal elastic membrane and tunica media. Angiograms obtained 3 and 6 months after PTA disclosed persistence of dilatation of t...Continue Reading

Citations

Feb 1, 1996·Journal of Endovascular Surgery : the Official Journal of the International Society for Endovascular Surgery·R Kachel
Dec 1, 1991·Journal of Clinical Laser Medicine & Surgery·M HaraY Konishi

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