Percutaneous valve replacement: significance of different delivery systems in vitro and in vivo

Cardiovascular and Interventional Radiology
Tim AttmannStefan Muller-Hulsbeck

Abstract

Percutaneous heart valve replacement is an exciting growing field in cardiovascular medicine yet still with some major problems. Only sophisticated improvement of the instruments could make it a real alternative to conventional surgery. Therefore, the aim of this study was to evaluate different delivery devices for percutaneous heart valve replacement in vitro and in vivo. A catheter prototype designed by our group, and two commercially available devices for the delivery of esophageal stents and aortic endoprostheses, were tested. After in vitro experiments, an ovine animal model of transfemoral pulmonary valve implantation was established using biological valved self-expanding stents. Only the delivery device for aortic endografts (Medtronic, Talent, Santa Rosa, CA, USA) allowed fast in vitro procedures without material fatigue. This device was chosen for the in vivo tests. Technical success was achieved in 9 of 10 animals (90%). One animal died after perforation of the ventricular wall. Orthotopic pulmonary placement was performed in 6 animals and intentional supravalvular valved stent placement in 3 animals. An adequate in vitro model for this evolving field of interventional heart valve replacement is presented. Furthermore...Continue Reading

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Citations

May 5, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mathieu VergnatLudwig Karl Von Segesser
Dec 4, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Cleonie JayasuriyaBrad Munt
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May 6, 2008·The Journal of Thoracic and Cardiovascular Surgery·René QuadenGeorg Lutter
Feb 13, 2016·Annals of Biomedical Engineering·Marco BartoschBoris Schmitt

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