Percutaneous vertebroplasty versus non-operative treatment for osteoporotic vertebral compression fractures: a meta-analysis of randomized controlled trials

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
S LouY Wang

Abstract

Osteoporotic vertebral compression fractures (OVCFs) are common in the elderly population and are often treated using percutaneous vertebroplasty (PVP). However, the effectiveness of PVP reported by various randomized controlled trials (RCTs) is inconclusive. This study aimed to analyze, from published literature, the efficacy and safety of PVP for OVCFs. A search was conducted in Medline, EMBASE, and Cochrane Libraries since their respective inception on January 1, 2019, for RCTs of OVCFs treated with PVP compared with non-operative treatment. The primary outcomes were pain relief at 1 to 2 weeks, 1 to 3 months, and 6 to 12 months. The secondary outcome was the rate of occurrence of new vertebral fractures. Meta-analysis was performed using a random effect model. A total of 13 RCTs comprising 1624 patients were included. For the blinded studies, statistical differences were found between PVP and the sham injection group for the 3 primary outcomes in the subgroup of the Vertebroplasty for Acute Painful Osteoporotic fractURes (VAPOUR) trial. Although pain scores were similar between the PVP group and the sham injection group for the VAPOUR trial at each period, the effect size of PVP increased over time. For the open-label studi...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G JonesJ A Eisman
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 26, 1999·Journal of Endocrinological Investigation·J A Kanis, O Johnell
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 20, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O Johnell, J A Kanis
Oct 18, 2007·Injury·Heidi PratherLouis A Gilula
Feb 5, 2009·JAMA : the Journal of the American Medical Association·Dana BliucJacqueline R Center
Aug 7, 2009·The New England Journal of Medicine·Rachelle BuchbinderBridie Murphy
Aug 7, 2009·The New England Journal of Medicine·David F KallmesJeffrey G Jarvik
Nov 4, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Hao-Kuang WangPo-Chou Liliang
Mar 4, 2011·The Journal of the American Academy of Orthopaedic Surgeons·Stephen I EssesKristin Hitchcock
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Apr 20, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jordi BlascoPilar Peris
Jun 26, 2012·Clinical Orthopaedics and Related Research·Ming-Min ShiShi-Gui Yan
Apr 30, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F BorgströmC Miltenburger
Dec 10, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Dong ChenHui Qin
Sep 18, 2015·Neurosurgery·Christina L GoldsteinR Douglas Orr

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Citations

Mar 15, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Terrence DiamondVal Gebski
Aug 25, 2020·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Weiran HuYanzheng Gao
Dec 16, 2020·Orthopaedics & Traumatology, Surgery & Research : OTSR·Solène ProstBenjamin Blondel
Jun 23, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A N FreiD Aujesky
Nov 26, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Wenle LiChengliang Yin

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