PMID: 9167839May 1, 1997Paper

Perfluoro-15-crown-5-ether labelled macrophages in adoptive transfer experimental allergic encephalomyelitis

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
U NöthJ Lutz

Abstract

In this serial in vivo study, macrophages labelled with perfluoro-15-crown-5-ether (15C5) were monitored in rats after inducing adoptive transfer experimental allergic encephalomyelitis (AT-EAE). AT-EAE is an animal model of multiple sclerosis and is characterized by inflammatory infiltrates in the central nervous system (CNS) and breakdown of the blood-brain-barrier. A particular feature of AT-EAE are macrophage infiltrates. Purpose of this study was to monitor the invasive and evasive phase of the macrophages in AT-EAE by using 3-dimensional 19F magnetic resonance imaging (3D 19F-MRI). In the early stage of the disease, a much stronger 19F-signal intensity was observed in AT-EAE-rats than in healthy control rats in the tissue adjacent to CNS regions severely affected by inflammatory infiltrates, and thereafter the 19F-signal intensity was decreasing over the time. However, no 19F-signal could be observed in the CNS itself neither in AT-EAE-rats nor in control rats. According to these findings it is assumed that we monitored the evasion of the macrophages from the region of inflammation.

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Citations

Sep 10, 2013·Nature Reviews. Immunology·Eric T Ahrens, Jeff W M Bulte
Mar 7, 2014·Pharmaceutical Research·Dan WangHua Ai
Sep 11, 2012·Biomaterials·Mangala SrinivasMathias Hoehn
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Mar 17, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Guido StollPeter Jakob
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