Perfluorobutanesulfonic acid (PFBS) potentiates adipogenesis of 3T3-L1 adipocytes

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Weipeng QiYeonhwa Park

Abstract

Perfluorobutanesulfonic acid (PFBS) is used as the replacement of perfluorooctanesulfonic acid (PFOS) since 2000 because of the concern on PFOS' persistence in the environment and the bioaccumulation in animals. Accumulating evidence has shown the correlation between the exposure to perfluorinated compounds and enhanced adipogenesis. There is no report, however, of the effect of PFBS on adipogenesis. Therefore, the present work aimed to investigate the role of PFBS in adipogenesis using 3T3-L1 adipocytes. PFBS treatment for 6 days extensively promoted the differentiation of 3T3-L1 preadipocytes to adipocytes, resulting in significantly increased triglyceride levels. In particular, the treatments of PFBS at the early adipogenic differentiation period (day 0-2) were positively correlated with increased the triglyceride accumulation on day 6. PFBS treatments significantly increased the protein and mRNA levels of the master transcription factors in adipocyte differentiation; CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor gamma (PPARγ), along with acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), the key proteins in lipogenesis. PFBS significantly activated the phosphorylation of e...Continue Reading

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Citations

Sep 22, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karilyn E SantAlicia R Timme-Laragy
Sep 18, 2020·Food Additives & Contaminants. Part B, Surveillance·Xueping WangYongning Wu
May 12, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karen ChiuWenyan Mei
Oct 10, 2020·Scientific Reports·Andrea Di NisioCarlo Foresta
Jan 30, 2021·Innate Immunity·Alexandra HöpfingerAndreas Schmid
Aug 25, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yiren YueYeonhwa Park
Nov 20, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Joseph M BraunKimberly Yolton
Nov 5, 2020·Journal of Toxicology and Environmental Health. Part a·Ola WaselJennifer L Freeman
Jan 1, 2020·Toxicological and Environmental Chemistry·Weipeng QiYeonhwa Park

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