Perfluorocarbon attenuates inflammatory cytokines, oxidative stress and histopathologic changes in paraquat-induced acute lung injury in rats

Environmental Toxicology and Pharmacology
Zahra KhalighiKhairollah Asadollahi

Abstract

The effects of perfluorocarbon (PFC) on paraquat (PQ) induced acute lung injury (ALI) was evaluated among rats. Twenty four Wistar rats were divided into 4 groups: control group injected by saline physiologic 0.9%, PFC group injected by Perfluorocarbon, PQ group injected by PQ and PQ+PFC group injected by PFC one hour after receiving paraquat. Bronchoalveular fluid content, inflammatory cytokines, oxidative and histopathologic changes were measured after 72 h. The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1(TGF-β1) in the PQ group were increased compared to either control or PFC groups, but their levels decreased in PQ+PFC group significantly (p<0.05). Also, histopathologic evaluation revealed an increase in malondialdehyde (MDA) and hydroxyproline (HP) in the PQ group but a decrease in PQ+PFC group significantly (p<0.01). PFC emulsion by its anti-inflammatory, anti-oxidative and anti-fibrotic properties can reduce the inflammatory and fibrotic alterations, pulmonary oedema, and pulmonary histopathologic changes created by PQ.

References

Jan 1, 1995·Respiration; International Review of Thoracic Diseases·S A PapirisS H Constantopoulos
Feb 1, 1997·Annals of Emergency Medicine·W Klein-Schwartz, G S Smith
Aug 4, 2007·Biochemical and Biophysical Research Communications·Kei-ichi FukudaShigeo Ohta
Jun 7, 2008·Experimental Biology and Medicine·Ercan GöcgeldiMetin Hasde
Nov 17, 2009·British Journal of Pharmacology·Syamantak MajumderSuvro Chatterjee
Apr 7, 2010·Expert Opinion on Investigational Drugs·Ken-ichiro Inoue, Hirohisa Takano
Dec 25, 2010·Journal of Biochemical and Molecular Toxicology·José M MoránJosé M Fuentes
Mar 23, 2011·American Journal of Respiratory Cell and Molecular Biology·Shihui SunYusen Zhou
Feb 26, 2013·The Journal of Surgical Research·Luiz Alberto ForgiariniCristiano Feijó Andrade
Apr 19, 2013·Inflammation·Keyvan Amirshahrokhi, Shahab Bohlooli
Apr 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yan ChenPei-bo Li

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Citations

Dec 18, 2018·Frontiers in Physiology·Michaël SageÉtienne Fortin-Pellerin
Feb 21, 2019·Experimental and Therapeutic Medicine·Jie HuangWeiwei Zhang
Feb 3, 2021·Critical Reviews in Toxicology·Rajasekaran Subbiah, Rajnarayan R Tiwari
Oct 31, 2020·Computational and Mathematical Methods in Medicine·Haihao Jin

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