Perfluoroctyl bromide as a blood pool contrast agent for computed tomographic angiography

Academic Radiology
S A FrumanM E Bernardino

Abstract

We determined whether perfluoroctyl bromide (perflubron) could be used as a computed tomography (CT) angiographic agent by studying vessel visibility (celiac artery, superior mesenteric artery [SMA], and renal arteries) with spiral CT and three-dimensional (3D) reconstructions. Five rhesus monkeys were examined with a perflubron emulsion (90% [w/v] perfluorochemical; administered intravenously at a dose of 1.5 ml/kg and at a rate of 0.5 ml/sec. Spiral CT was performed immediately and at 5 hr after injection. Three dimensional images of the aorta at the level of the celiac artery, SMA, and renal arteries were reconstructed and blindly rated 0-4 (0 = not seen; 4 = excellent visualization) by two observers. All the vessels had the best ratings immediately after injection: celiac artery, 2.8 +/- 0.42; SMA, 2.7 +/- 0.48; left renal artery, 2.1 +/- 0.99; and right renal artery, 1.2 +/- 1.03. The ratings after the 5-hr delay were as follows: celiac artery, 1.3 +/- 1.34; SMA, 1.5 +/- 1.08; left renal artery, 1.5 +/- 0.97; and right renal artery, 1.2 +/- 0.79. Spiral CT angiography with a perflubron emulsion successfully demonstrated all vessels immediately and at 5 hr after contrast agent infusion. Further refinements of the dose, rate...Continue Reading

References

Oct 1, 1993·Radiology·M GalanskiJ E Nischelsky
Apr 1, 1993·AJR. American Journal of Roentgenology·R K ZemanC J Cooper

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Citations

Mar 20, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Bulent AydoganPeter Redmond
Feb 25, 2006·The British Journal of Radiology·J F HainfeldH M Smilowitz
Jul 22, 2010·Physics in Medicine and Biology·Ji LiBulent Aydogan
Mar 17, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Wen-Yen Huang, Jason J Davis

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