Perfluorooctanoic acid stimulates ovarian cancer cell migration, invasion via ERK/NF-κB/MMP-2/-9 pathway

Toxicology Letters
Xiaozhao LiXuesen Zhang

Abstract

As widely used in consumer products, perfluorooctanoic acid (PFOA) has become a common environmental pollutant, which has been detected in human serum and associated with cancers. Our previous study showed that PFOA is a carcinogen that promotes endometrial cancer cell migration and invasion through activation of ERK/mTOR signaling. Here, we showed that PFOA (≥100 nM) treatment also stimulated A2780 ovarian cancer cell invasion and migration, which correlated with increased matrix metalloproteinases MMP-2/-9 expression, important proteases associated with tumor invasion and migration. Notably, PFOA treatment induced activation of ERK1/2/ NF-κB signaling. Pre-treatment with U0126, an ERK1/2inhibitor;or JSH-23, a NF-kB inhibitor, can reverse the PFOA-induced cell migration and invasion. Consistent with these results, inhibiting ERK1/2 or NF-κB signaling abolished PFOA-induced up-regulation of MMP-2/-9 expression. These results indicate that PFOA can stimulate ovarian cancer cell migration, invasion and MMP-2/-9 expression by up-regulating ERK/NF-κB pathway.

Citations

May 10, 2019·Cancer Cell International·Shentong YuJing Zhang
May 14, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Fu XiaomengYuan Dandan
Mar 29, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·John T SzilagyiRebecca C Fry
Mar 8, 2020·International Journal of Environmental Research and Public Health·Alexis M TemkinLisa M Kamendulis
Sep 22, 2018·Cell Death & Disease·Huey-En TzengShih-Wei Wang
Jan 19, 2021·CNS Neuroscience & Therapeutics·Yu-Hua HuJian-Liang Wu
Jan 8, 2021·OncoTargets and Therapy·Huaming WeiWeiLi Hu
Mar 24, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xishuang WangXiaoyan Wang
Nov 26, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lei ZhengLiming Gao
Sep 1, 2021·Journal of Molecular Histology·Heng ChenGuoliang Sa
Feb 12, 2020·Ecotoxicology and Environmental Safety·Heng LiDan Xu

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