Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice.

Infection and Immunity
P LaochumroonvorapongG Kaplan

Abstract

Host defense against mycobacterial infection requires the participation of monocytes and T cells. Both CD4+ and CD8+ T cells have been shown to be important in resistance to mycobacterial infection in vivo. The main contribution of CD4+ T cells to the protective antituberculosis response involves the production of Th1-type cytokines, including interleukin-2 (IL-2) and gamma interferon (IFN-gamma). CD8+ T cells have been considered to be responsible primarily for cytotoxicity mediated by toxic molecules, including perforin. CD8+ T cells may also elaborate Th1-type cytokines, such as IFN-gamma, in response to the infection. To elucidate the contribution of perforin-mediated target cell death to the control of mycobacterial infection in vivo, mice with a disruption in the perforin gene (P-/-) were infected with Mycobacterium bovis BCG or M. tuberculosis Erdman for 5 and 13 weeks, respectively. At 1, 3, 5, and 13 weeks postinfection, the number of viable mycobacteria in the lungs, spleens, and livers of mice were determined by CFU assay. The infected tissues were examined histologically, and cytokine mRNA levels in the spleens of these mice were determined. Similar studies were carried out in Fas receptor-defective (CBA/lpr(cg)) mi...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L FlynnB R Bloom
Sep 1, 1989·The Journal of Experimental Medicine·M P HayesP A Henkart
Mar 1, 1994·The Journal of Experimental Medicine·T Suda, S Nagata
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C M WalshW R Clark
Mar 10, 1995·Science·S Nagata, P Golstein
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
Jun 1, 1993·The Journal of Experimental Medicine·A MolloyG Kaplan
Apr 1, 1995·Immunology Today·C C LiuJ D Young

❮ Previous
Next ❯

Citations

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·A LalvaniA V Hill
Feb 13, 2001·American Journal of Respiratory Cell and Molecular Biology·J TurnerA M Cooper
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M UmemuraY Yoshikai
Apr 5, 2001·FEMS Microbiology Letters·C L SilvaS C Leão
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D H CanadayW H Boom
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Vanja Lazarevic, JoAnne Flynn
Sep 13, 2003·American Journal of Respiratory and Critical Care Medicine·Deborah A LewinsohnDavid M Lewinsohn
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael WalchUrs Ziegler
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dhruv SudDenise E Kirschner
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua S WoodworthSamuel M Behar
Jul 9, 2009·European Journal of Immunology·Peiying HoGeok Teng Seah
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D M LewinsohnM R Alderson
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N V SerbinaJ L Flynn
Nov 11, 1999·Clinical and Experimental Immunology·S J OliverG Kaplan
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M SmithH M Dockrell
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z XingS K Sharma
Jun 13, 1998·The Journal of Experimental Medicine·D M LewinsohnK H Grabstein
Mar 13, 2001·Annual Review of Immunology·J L Flynn, J Chan
Dec 2, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Claudia MancaGilla Kaplan
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carl G FengAlan Sher
Dec 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua S WoodworthSamuel M Behar
Feb 26, 2011·Immunological Reviews·Deborah A LewinsohnDavid M Lewinsohn
Jun 22, 1999·The Journal of Experimental Medicine·S M BeharM B Brenner
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I V LyadovaA S Apt
Aug 23, 2001·Scandinavian Journal of Infectious Diseases·S Stenger
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·A O SousaB R Bloom
May 31, 2001·Immunology·H L Collins, S H Kaufmann
Jul 20, 2012·Clinical & Developmental Immunology·Mayra Silva MirandaFrederic Altare
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael WalchUrs Ziegler
Feb 1, 2017·Nature Reviews. Immunology·Ine JorgensenEdward A Miao
Jun 3, 2000·Annual Review of Immunology·J T HartyD W White

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.