PMID: 3292393Mar 1, 1988Paper

Perforin-dependent and -independent pathways of cytotoxicity mediated by lymphocytes

Immunological Reviews
J D YoungZ A Cohn

Abstract

There is little doubt at the present time that both perforin-dependent and -independent pathways are important in mediating the cytotoxicity associated with lymphocytes. The cell distribution of perforin, initially thought to include both CTL and NK cells, now must be viewed with caution because all previous biochemical studies on CTL have been conducted with cell lines propagated in long-term cultures in the presence of T cell growth factors (IL-2 and perhaps some still undefined factors). Under these conditions, CTL are known to assume a broader, NK-like specificity in target cell killing and may thus differ significantly from primary CTL generated in the body. Accordingly, perforin does not seem to be present in primary CTL activated directly through mixed lymphocyte reactions. It remains to be shown how primary CTL lyse target cells in vivo. Initial studies conducted in several laboratories have already provided some clues. It now seems that even in cultured, perforin-containing CTL, the perforin pathway is not an obligatory mechanism required for target cell killing. Other pathways, possibly involving TNF/lymphotoxin-like molecules, may play a direct role in this type of cytotoxicity. Other still unidentified factors now a...Continue Reading

References

Jan 20, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C J Sanderson
Jan 20, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C J Sanderson
Jul 1, 1977·Physiological Reviews·A D Macknight, A Leaf
Jul 14, 1977·Nature·S Gillis, K A Smith
Jan 1, 1978·European Journal of Immunology·B Kahn-Perles, P Golstein
Jan 1, 1977·Contemporary Topics in Immunobiology·P Golstein, E T Smith
Jun 26, 1975·Nature·J Ferluga, A C Allison
Jul 1, 1975·Cellular Immunology·A I GrayzelG S Lazarus
Mar 1, 1976·The Journal of Experimental Medicine·R C Kuppers, C S Henney
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Nov 8, 1985·Science·L J Old
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E R PodackZ A Cohn
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J D YoungZ A Cohn
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L S ZalmanH J Müller-Eberhard
Feb 1, 1987·The Journal of Experimental Medicine·L S ZalmanH J Müller-Eberhard
Sep 1, 1987·The Journal of Experimental Medicine·H Takayama, M V Sitkovsky
Nov 1, 1987·The Journal of Experimental Medicine·C R VerretH N Eisen
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D M Kranz, H N Eisen
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B S KwonS M Weissman
Jun 25, 1985·Nucleic Acids Research·L FransenA Van Vliet
Jul 1, 1987·The Journal of Experimental Medicine·S TrevesT Pozzan
Jan 1, 1986·Advances in Immunology·P Marrack, J Kappler

❮ Previous
Next ❯

Citations

Sep 1, 1993·The Histochemical Journal·G Bou-GhariosI Olsen
Feb 1, 1989·Immunology Letters·M Nabholz, J Tschopp
Jan 1, 1990·Immunology Today·P J PetersJ Borst
Jan 1, 1996·Human Immunology·B SusskindT Mohanakumar
Dec 1, 1994·Journal of the American College of Cardiology·R D EnsleyW H Barry
Jan 1, 1991·Electron Microscopy Reviews·I Vollenweider, P Groscurth
Apr 21, 1994·The New England Journal of Medicine·L G Lange, G F Schreiner
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M J GrusbyL H Glimcher
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·S HanabuchiK Okumura
Apr 1, 1990·The Journal of Experimental Medicine·M J SmythH A Young
May 1, 1992·The Journal of Experimental Medicine·A FrancoV Barnaba
Jan 1, 1994·The Journal of Experimental Medicine·R M Steinman, C L Moberg
Jan 1, 1991·Clinical Immunology and Immunopathology·R V BowmanB W Robinson
Oct 8, 2013·Journal of Hepatology·Pranavkumar ShivakumarJorge A Bezerra
Jul 1, 2017·Cell Death and Differentiation·Conor J KearneyJane Oliaro
May 1, 1994·Circulation·W H Barry
Aug 1, 1995·Immunological Reviews·C C LiuJ D Young
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P A SteerenbergE J Ruitenberg
Jan 1, 1991·European Journal of Immunology·S D Hudnall
Mar 1, 1991·European Journal of Immunology·G M GriffithsI Weissman
Sep 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A Cesano, D Santoli
Nov 1, 1989·Immunological Investigations·Y Q Wei, Z B Hang
Mar 8, 2018·Current Protocols in Immunology·John WonderlichMatthew M Presby
May 15, 1989·International Journal of Cancer. Journal International Du Cancer·L RivoltiniG Parmiani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
H X Yang, R E Mitchel
© 2022 Meta ULC. All rights reserved