Perforin: more than just a pore-forming protein

International Reviews of Immunology
Fang Zhou

Abstract

Cellular apoptosis induced by T cells is mainly mediated by two pathways. One, granule exocytosis utilizes perforin/granzymes. The other involves signaling through death receptors of the TNF-alpha R super-family, especially FasL. Perforin plays a central role in apoptosis induced by granzymes. However, the mechanisms of perforin-mediated cytotoxicity are still not elucidated completely. Perforin is not only a pore-forming protein, but also performs multiple biological functions or perforin performs one biological function (cytolysis), but has multiple biological implications in the cellular immune responses, including regulation of proliferation of CD8+ CTLs.

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Citations

Dec 18, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Amélie E CoudertMarie-Christine de Vernejoul
Nov 4, 2015·Nature Reviews. Cardiology·Xiao MengYun Zhang
Apr 5, 2012·Clinical and Experimental Immunology·I Sada-OvalleL Torre-Bouscoulet
Aug 9, 2020·Frontiers in Cellular and Infection Microbiology·Maíra Garcia SaldanhaSérgio Arruda
Aug 2, 2017·International Journal of Molecular Sciences·Robin C Willenbring, Aaron J Johnson

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