PMID: 3767272Jul 1, 1986Paper

Performance and clinical utility of a commercially available 'C-terminal' PTH assay

Annals of Clinical Biochemistry
A R IngleJ S Harrop

Abstract

The performance and clinical utility of a 'C-terminal' parathyroid hormone (PTH) radioimmunoassay (Dac-Cel, Wellcome Diagnostics) is described. Parathyroid hormone, as measured by the Dac-Cel method, is stable in whole blood samples for at least 24 h. 84% of patients with hypercalcaemia due to primary hyperparathyroidism have values above the upper limit seen in normocalcaemic subjects (0.5 micrograms/L), with detectable serum PTH demonstrable in the remaining 16%. In patients with hypocalcaemia due to hypoparathyroidism serum PTH was undetectable in 73% and 'inappropriately' low in the remainder. In 50% of patients with malignancy-associated hypercalcaemia serum PTH was undetectable, but was above 0.5 micrograms/L in 13%. Increased PTH concentrations were invariably found in patients with renal failure. The Dac-Cel method is a reliable and robust technique for measurement of PTH and in conjunction with determination of calcium facilitates the diagnosis of primary parathyroid disorders. Caution is required in the interpretation of PTH measurements in patients with renal failure; the significance of detectable PTH in some patients with malignancy-associated hypercalcaemia is not clear.

References

May 13, 1978·Lancet·M K Drezner, H E Lebovitz
Nov 15, 1979·The New England Journal of Medicine·K J MartinE Slatopolsky
Nov 1, 1979·Annals of Internal Medicine·J F Habener, G V Segre
Nov 1, 1976·Annals of Clinical Biochemistry·J S Woodhead, D A Walker
Aug 1, 1985·The Journal of Clinical Investigation·G R MundyS M D'Souza
Jul 1, 1968·The Journal of Clinical Endocrinology and Metabolism·S A Berson, R S Yalow
Nov 26, 1983·British Medical Journal·W Van'T HoffE J Bicknell
Apr 1, 1982·Journal of Clinical Pathology·J S HarropJ S Woodhead
May 1, 1982·Clinical Endocrinology·S AdamiJ L O'Riordan
Nov 1, 1981·Clinical Endocrinology·R M ManningJ L O'Riordan
Jan 24, 1980·The New England Journal of Medicine·H HeathM A Kennedy
May 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·S A BersonJ T Potts

❮ Previous
Next ❯

Citations

Nov 1, 1989·Annals of Clinical Biochemistry·S P ThompsonE Pawley
Jan 1, 1992·Annals of Clinical Biochemistry·P J Wood
Jul 1, 1988·Annals of Clinical Biochemistry·E J Bicknell, W Van't Hoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.