Performance and sample size requirements of Bayesian methods for binary outcomes in fixed-dose combination drug studies

Journal of Biopharmaceutical Statistics
Melinda M HoltDean M Young

Abstract

We develop a Bayesian analysis for the study of fixed-dose combinations of two or more drugs. The approach described here does not require knowledge of the dose-response relationships of the components or large sample approximations. We provide a procedure to estimate sample size in this context. In addition, we explore the performance of the Bayesian procedure in situations where existing methods are known to perform poorly.

References

Dec 1, 1989·Statistics in Medicine·J M Gibson, J E Overall
Sep 1, 1987·Statistics in Medicine·S M Snapinn
Feb 15, 1996·Statistics in Medicine·H M Hung
Apr 15, 1997·Statistics in Medicine·L JosephP Bélisle
Oct 23, 1997·Statistics in Medicine·E M LaskaD I Tang
Jul 6, 2001·Statistics in Medicine·K H Zou, S L Normand
Nov 5, 2002·Journal of Biopharmaceutical Statistics·A James O'MalleyRichard E Kuntz

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Citations

Jun 22, 2013·Journal of Biopharmaceutical Statistics·James D StameyJohn W Seaman

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Software Mentioned

R
Mathematica

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