Performance at preoperative stair-climbing test is associated with prognosis after pulmonary resection in stage I non-small cell lung cancer

The Annals of Thoracic Surgery
Alessandro BrunelliArmando Sabbatini

Abstract

This investigation evaluated whether the performance at a preoperative symptom-limited stair-climbing test was a prognostic factor in resected pathologic stage I non-small cell lung cancer (NSCLC). Observational analysis was performed on a prospective database that included 296 patients who underwent pulmonary lobectomy for pathologic stage T1 N0 or T2 N0 NSCLC (2000 to 2008). Patients who received induction chemotherapy were excluded. Survival was calculated by the Kaplan-Meyer method. The log-rank test was used to assess differences in survival between groups. The relationships between survival and baseline and clinical variables were determined by Cox multivariate analyses. Median follow-up was 43 months. The best cutoff associated with prognosis was an 18-meter stair climb. Median (months) survival and 5-year survival of patients who climbed more than 18 meters were significantly longer than those who climbed less than 18 meters (97 vs 74; 77% vs 54%, p=0.001). Cox regression model (hazard ratio) showed that climbing more than 18 meters (0.5; p=0.003), diffusion capacity of the lung for carbon monoxide (0.98; p=0.02), and pT stage (1.8; p=0.02) were independent prognostic factors. Patients who climbed less than 18 meters ha...Continue Reading

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Citations

Oct 24, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Cecilia PompiliAlessandro Brunelli
Feb 22, 2013·Interactive Cardiovascular and Thoracic Surgery·Satoshi ShionoToru Sato
Feb 28, 2016·Journal of the American College of Surgeons·Sushanth ReddyMartin J Heslin
May 9, 2013·The Journal of Thoracic and Cardiovascular Surgery·Alessandro BrunelliCecilia Pompili
May 29, 2012·The Annals of Thoracic Surgery·Douglas Mathisen
Sep 1, 2015·Revue de pneumologie clinique·M RiquetE Fabre
Feb 28, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomasz MarjanskiWitold Rzyman
May 26, 2015·The Annals of Thoracic Surgery·Alessandro BrunelliGonzalo Varela
Apr 15, 2015·General Thoracic and Cardiovascular Surgery·Naoko MiuraHideki Yokoyama
Apr 1, 2015·Archivos de bronconeumología·Francisco García-Río
May 10, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Duc HaMark Fuster
Dec 4, 2016·Asian Cardiovascular & Thoracic Annals·Asra HashmiShirish M Gadgeel
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Sep 19, 2019·American Journal of Physiology. Cell Physiology·Blas A GuigniMichael J Toth
Sep 12, 2018·Interactive Cardiovascular and Thoracic Surgery·Tomasz MarjanskiWitold Rzyman
Aug 8, 2020·General Thoracic and Cardiovascular Surgery·Naoki OzekiToyofumi Fengshi Chen-Yoshikawa
Sep 20, 2020·The Journal of Thoracic and Cardiovascular Surgery·Alessandro BrunelliKostas Papagiannopoulos
Apr 29, 2021·Scandinavian Journal of Medicine & Science in Sports·Yasmin EzzatvarAntonio García-Hermoso
Aug 22, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cindy de Oliveira VacchiFabrício Edler Macagnan

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