Performance characteristics of platelet autoantibody testing for the diagnosis of immune thrombocytopenia using strict clinical criteria.

British Journal of Haematology
Caroline GabeDonald M Arnold

Abstract

Misclassification of immune thrombocytopenia (ITP) is common, which might undermine the value of platelet autoantibody testing. We determined the sensitivity and specificity of platelet autoantibody testing using the direct antigen capture assay for anti-glycoprotein (GP) IIb/IIIa or anti-GPIbIX in patients with 'definite ITP', defined as those with a documented treatment response. Sensitivity of platelet autoantiboody testing increased from 48·3% [95% confidence interval (CI) 43·5-53·2] for all ITP patients to 64·7% (95% CI 54·6-73·9) for definite ITP patients. Specificity was unchanged [75·3% (95% CI 67·5-82·1)]. High optical density values (>0·8) improved the specificity of platelet autoantibody testing but lowered sensitivity. In patients with a high pretest probability, platelet autoantibodies can aid in the diagnosis of ITP and may be most prevalent in certain patient subsets.

References

Jun 5, 2007·British Journal of Haematology·Lemke K PageJames B Bussel
May 29, 2018·British Journal of Haematology·Leendert PorcelijnMasja de Haas
Mar 30, 2019·Haematologica·Richard VollenbergUlrich J Sachs
Dec 4, 2019·Blood Advances·Cindy NeunertSara K Vesely
Oct 14, 2020·Transfusion Medicine Reviews·Leendert PorcelijnMasja de Haas

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Citations

Sep 9, 2021·British Journal of Haematology·James B Bussel, Ellinor Peerschke

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