Performance characteristics of putative tests for subclinical chorioamnionitis

Infectious Diseases in Obstetrics and Gynecology
R K EdwardsP Duff

Abstract

To evaluate amniotic fluid glucose, matrix metalloproteinase (MMP)-9, interleukin (IL)-6, and IL-12 for diagnosing subclinical chorioamnionitis in women with preterm labor. Forty-four women in preterm labor at 22-35 weeks gestation with suspected subclinical chorioamnionitis underwent amniocentesis. Amniotic fluid analysis included Gram stain, culture, and determination of glucose, MMP-9, IL-6, and IL-12 concentrations. Median values of these analytes were compared using the Mann-Whitney U test. Sensitivity, specificity, and positive and negative predictive values were calculated for tests using a positive amniotic fluid culture or delivery within 24 hours as the key outcome variables. Amniotic fluid concentrations of glucose, MMP-9, and IL-6 correlated closely with positive culture or delivery within 24 hours. IL- 12 concentrations did not correlate with either a positive culture or delivery within 24 hours. Amniotic fluid glucose, MMP-9, and IL-6 reliably predict microbial invasion of the amniotic cavity or imminent delivery. IL- 12 values did not correlate with amniotic fluid culture results or imminent delivery.

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Citations

May 31, 2008·American Journal of Perinatology·Catalin S BuhimschiIrina A Buhimschi
Jan 18, 2007·PLoS Medicine·Catalin S BuhimschiIrina A Buhimschi
Sep 16, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rocio RevelloJose L Bartha
May 29, 2007·Seminars in Perinatology·Shali Mazaki-ToviSonia S Hassan
Oct 25, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·C S BuhimschiI A Buhimschi
Jan 22, 2015·American Journal of Reproductive Immunology : AJRI·Antonette T DulayIrina A Buhimschi
Jan 28, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Seung Mi LeeBo Hyun Yoon
Feb 3, 2009·American Journal of Obstetrics and Gynecology·Humberto AzpuruaCatalin S Buhimschi
Mar 3, 2007·Obstetrics and Gynecology·Christian M PettkerCatalin S Buhimschi
Feb 2, 2008·Obstetrics and Gynecology·Irina A BuhimschiCatalin S Buhimschi
Oct 13, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Vineet BhandariIrina A Buhimschi
Jun 26, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyIvana Musilova
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antonette T DulayIrina A Buhimschi

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