PMID: 15224763Jul 1, 2004Paper

Performance characteristics of the Coulter LH 500 hematology analyzer

Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
Sandra KaplanIan Chin Yee

Abstract

The challenge for modern hematology laboratories is to provide accurate and reproducible results, with seamless performance between facilities, in a cost-effective manner. Beckman Coulter recently developed the Coulter LH 500 to meet the needs of smaller laboratories or serve as a backup in larger laboratories. The principal goal of this study was to validate all parameters and performance specifications of the LH 500 compared to the Coulter LH 750 predicate analyzer. A total of 245 spent clinical samples from the London Health Sciences Centre (LHSC) and 251 from the University of Pittsburgh Medical Center Health System (UPMCHS) were analyzed during the study. The samples were selected to include 75% abnormal and 25% normal blood samples. According to the results of a rank sum test, there was no significant difference between the LH 500 and LH 750 for all complete blood count parameters (P > .05) except the red cell distribution width, which showed a slight negative bias on the LH 500. Differential parameters comparing the LH 500 to a 400-cell manual differential showed correlation coefficients (r2) from 0.75 to 0.99 for all parameters except basophils. Of the samples run on the LH 500 at LHSC, the false-positive differential f...Continue Reading

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Citations

Apr 9, 2004·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·C AulesaR Galimany
Jul 1, 2004·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Anthony D La PortaSharon Barr
Mar 26, 2005·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Neil HarrisAlexander Kratz
Jul 1, 2004·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·J LuiderI Auer
Feb 16, 2006·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·G BournerJ Sumner
Nov 23, 2006·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·C Aulesa, M Prieto
Mar 20, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kazuhiko KotaniToshiyuki Yamada
Sep 29, 2018·Journal of the International Society of Sports Nutrition·Emma M CrumStephen R Stannard

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