Abstract
To compare the diagnostic performance of three rapid antigen detection tests (RADTs) for group A Streptococcus (GAS). A hospital-based, cross-sectional, retrospective study. A comparative study of rapid diagnostic tests for GAS using clinical specimens in a single institute. 225 children in the outpatient clinics ofKorea University Guro Hospitalwith suspicious symptoms were subjected to throat swab sampling. A dual-swab applicator was used. Samples were stored at below -70°C in a 10 mL transport tube containing 1 mL liquid Stuart's transport medium. All tests were performed in the laboratory by trained clinical laboratory scientists. Sensitivity, specificity, accuracy and kappa index of three RADTs were compared with the reference PCR test and culture results. Of the 225 patients suspected of having GAS, 67 and 90 were positive for GAS in the culture and PCR tests, respectively. Compared with the reference culture, the sensitivity for GAS was 92.5% (CI 83.4 to 97.5), 71.6% (CI 59.3 to 81.9) and 74.63% (CI 62.5 to 84.4) for careUS Strep A Plus, SD Bioline and BD Veritor, respectively, and the specificity was 97.0% (CI 93.1 to 99.0), 94.6% (CI 90.1 to 97.5) and 92.9% (CI 87.8 to 96.2) for careUS Strep A Plus, SD Bioline and BD Ve...Continue Reading
References
Nov 24, 2001·Annals of Emergency Medicine·L A DimatteoR Gonzales
Feb 13, 2003·Scandinavian Journal of Infectious Diseases·Christina NerbrandClaes Schalén
Jul 20, 2004·Clinical Microbiology Reviews·Michael A Gerber, Stanford T Shulman
Jul 23, 2004·The Journal of Antimicrobial Chemotherapy·Sunjoo Kim, Nam Yong Lee
Feb 3, 2005·Pediatrics·M Bruce Edmonson, Kathryn R Farwell
Jun 1, 2005·Pediatric Clinics of North America·Michael A Gerber
Oct 29, 2005·The Lancet Infectious Diseases·Jonathan R CarapetisMartin Weber
Mar 21, 2007·Nature Reviews. Microbiology·Shabir BanooUNKNOWN TDR Diagnostics Evaluation Expert Panel
Jul 27, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·N BuchbinderP Le Roux
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brad SpellbergUNKNOWN Infectious Diseases Society of America
Sep 4, 2009·The Korean journal of laboratory medicine·Sunjoo Kim
Feb 18, 2011·The New England Journal of Medicine·Michael R Wessels
Nov 4, 2011·The Journal of Pediatrics·Nader ShaikhEmma G Hooper
Oct 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stanford T ShulmanChris Van Beneden
Jul 13, 2013·BMC Infectious Diseases·Eileen M DunneAndrew C Steer
Sep 15, 2014·Journal of Virological Methods·Akira SakuraiFutoshi Shibasaki
Jun 13, 2015·Journal of Global Infectious Diseases·Beula SubashiniVeeraraghavan Balaji
Jul 7, 2015·Current Treatment Options in Pediatrics·Judith M Martin
Jul 5, 2016·The Cochrane Database of Systematic Reviews·Jérémie F CohenMartin Chalumeau
Jan 7, 2018·Journal of Clinical Microbiology·Gregory J BerryJohn R Petersen