Performance of a capnodynamic method estimating effective pulmonary blood flow during transient and sustained hypercapnia

Journal of Clinical Monitoring and Computing
Thorir SigmundssonH Björne

Abstract

The capnodynamic method is a minimally invasive method continuously calculating effective pulmonary blood flow (COEPBF), equivalent to cardiac output when intra pulmonary shunt flow is low. The capnodynamic equation joined with a ventilator pattern containing cyclic reoccurring expiratory holds, provides breath to breath hemodynamic monitoring in the anesthetized patient. Its performance however, might be affected by changes in the mixed venous content of carbon dioxide (CvCO2). The aim of the current study was to evaluate COEPBF during rapid measurable changes in mixed venous carbon dioxide partial pressure (PvCO2) following ischemia-reperfusion and during sustained hypercapnia in a porcine model. Sixteen pigs were submitted to either ischemia-reperfusion (n = 8) after the release of an aortic balloon inflated during 30 min or to prolonged hypercapnia (n = 8) induced by adding an instrumental dead space. Reference cardiac output (CO) was measured by an ultrasonic flow probe placed around the pulmonary artery trunk (COTS). Hemodynamic measurements were obtained at baseline, end of ischemia and during the first 5 min of reperfusion as well as during prolonged hypercapnia at high and low CO states. Ischemia-reperfusion resulted i...Continue Reading

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Citations

Feb 10, 2018·Journal of Clinical Monitoring and Computing·Philip J Peyton, Monique Kozub
Feb 28, 2019·BMC Anesthesiology·Philip J PeytonMagnus Hallbäck
Jan 26, 2020·Journal of Clinical Monitoring and Computing·D S KarbingM B Jaffe
Nov 21, 2019·Journal of Clinical Monitoring and Computing·Thorir Svavar SigmundssonHåkan Björne
Oct 6, 2021·Journal of Clinical Monitoring and Computing·Anders SvedmyrJacob Karlsson
Nov 11, 2021·Paediatric Anaesthesia·Jacob Karlsson, Per-Arne Lönnqvist

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