Performance of a malaria microscopy image analysis slide reading device.

Malaria Journal
W Roy PrescottChristopher Schwabe

Abstract

Viewing Plasmodium in Romanovsky-stained blood has long been considered the gold standard for diagnosis and a cornerstone in management of the disease. This method however, requires a subjective evaluation by trained, experienced diagnosticians and establishing proficiency of diagnosis is fraught with many challenges. Reported here is an evaluation of a diagnostic system (a "device" consisting of a microscope, a scanner, and a computer algorithm) that evaluates scanned images of standard Giemsa-stained slides and reports species and parasitaemia. The device was challenged with two independent tests: a 55 slide, expert slide reading test the composition of which has been published by the World Health Organization ("WHO55" test), and a second test in which slides were made from a sample of consenting subjects participating in a malaria incidence survey conducted in Equatorial Guinea (EGMIS test). These subjects' blood was tested by malaria RDT as well as having the blood smear diagnosis unequivocally determined by a worldwide panel of a minimum of six reference microscopists. Only slides with unequivocal microscopic diagnoses were used for the device challenge, n = 119. On the WHO55 test, the device scored a "Level 4" using the W...Continue Reading

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Citations

Sep 3, 2013·Malaria Journal·Yulia M SerebrennikovaJennifer M Smith
Dec 1, 2012·Journal of Medical Internet Research·Miguel Angel Luengo-OrozJohn Frean
Sep 26, 2013·The American Journal of Tropical Medicine and Hygiene·Sean C MurphyV Ann Stewart
Sep 8, 2017·Frontiers in Public Health·Joseph Joel PollakSeth J Salpeter
Dec 13, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Brian Gitta, Nicole Kilian

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Methods Mentioned

BETA
PCR

Software Mentioned

WHT

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