Performance of Acoustic Radiation Force Impulse Elastography for Staging Liver Fibrosis in Patients with Chronic Hepatitis C after Viral Eradication

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Sheng-Hung ChenCheng-Yuan Peng

Abstract

Data on noninvasive liver fibrosis staging after viral eradication is unclear. This histology-based study validated the performance of liver stiffness (LS) measurement after viral eradication. Consecutive participants with chronic hepatitis C (CHC) who received concomitant LS measurement through acoustic radiation force impulse (ARFI) elastography and percutaneous liver biopsy were prospectively screened and analyzed. Of the 644 patients, 521 (80.9%) underwent a biopsy at treatment baseline, and the remaining 123 (19.1%) underwent a biopsy at 3 (median) (interquartile range: 0.1) years after the sustained virological response (SVR) to pegylated interferon-based and direct-acting antiviral treatments.The proportions of histological fibrosis stages did not differ significantly between the pretreatment and post-SVR groups (P = .0615). However, the LS values differed significantly (P <.0001). The median LS values (presented as shear wave velocity in meters per second) were 1.51 (0.92) for the pretreatment group and 1.22 (0.77) for the post-SVR group. The cutoffs (areas under the receiver operating characteristic curve obtained using the bootstrap method) to dichotomize between METAVIR fibrosis stage F1 versus F2-F4, F1-F2 versus F3...Continue Reading

References

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Citations

Jun 17, 2020·Expert Opinion on Pharmacotherapy·Joeri LambrechtFrank Tacke
Jun 25, 2021·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.euUNKNOWN Panel members:
Jul 14, 2020·European Journal of Gastroenterology & Hepatology·Sheng-Hung ChenCheng-Yuan Peng
Aug 21, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sheng-Hung ChenCheng-Yuan Peng

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