Performance of CHA2 DS2 -VASc score for stroke prediction after surgical aortic valve replacement

The Journal of Thoracic and Cardiovascular Surgery
Tuomas O KiviniemiFausto Biancari

Abstract

Stroke is a frequent complication occurring early and late after surgical aortic valve replacement. There is an unmet clinical need for simple tools to assess postoperative stroke risk. We sought to assess the predictive performance of Congestive heart failure; Hypertension; Age ≥75 (doubled); Diabetes mellitus; prior Stroke, transient ischemic attack or thromboembolism (doubled); Vascular disease; Age 65 to 74; Sex category (female) (CHA2DS2-VASc) score in patients undergoing surgical aortic valve replacement with a bioprosthesis. Seven hundred fourteen patients undergoing isolated surgical aortic valve replacement with a bioprosthesis at 4 university hospitals were included. Data were collected retrospectively from patient records and monitored by an independent party. Median follow-up time was 4.8 years. Mean CHA2DS2-VASc score was 4.1 ± 1.6. Low (scores, 0-1), high (scores, 2-4), and very high (scores, 5-9) CHA2DS2-VASc scores were observed in 39 (5.5%), 400 (56.0%), and 262 (38.5%) patients, respectively. Incidences of stroke or transient ischemic attack at 1 year were 2.6%, 4.8%, and 10.7%; at 5 years incidences were 5.2%, 14.0%, and 21.9%; and at 10 years incidence were 5.2%, 20.7%, and 37.9% for patients in low, high, a...Continue Reading

References

Mar 20, 2012·The Journal of Thoracic and Cardiovascular Surgery·D Craig MillerUNKNOWN PARTNER Stroke Substudy Writing Group and Executive Committee
Mar 30, 2013·Circulation·J Matthew BrennanUNKNOWN DEcIDE AVR (Developing Evidence to Inform Decisions about Effectiveness–Aortic Valve Replacement) Research Team
Oct 6, 2015·The New England Journal of Medicine·Raj R MakkarLars Søndergaard
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Sep 19, 2016·International Journal of Cardiology·Antti PalomäkiK E Juhani Airaksinen
Dec 10, 2016·PloS One·Jussi JaakkolaK E Juhani Airaksinen
Sep 10, 2017·European Heart Journal·Helmut BaumgartnerUNKNOWN ESC Scientific Document Group

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