Performance of Determine Combo and other point-of-care HIV tests among Seattle MSM

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Joanne D SteklerMatthew Golden

Abstract

The rapid test study was a real-time comparison of point-of-care (POC) HIV tests to determine their abilities to detect early HIV infection. Men and transgender persons reporting sex with men in the prior year were recruited at the Public Health-Seattle & King County STD Clinic, Gay City Health Project, and University of Washington Primary Infection Clinic. Study tests included the OraQuick ADVANCE Rapid HIV-1/2 Antibody Test performed on oral fluids and tests performed on fingerstick whole blood specimens including OraQuick, Uni-Gold Recombigen HIV test, Determine HIV-1/2 Ag/Ab Combo, and INSTI HIV-1 Rapid Antibody Test. Specimens from subjects with negative results were sent for EIA and nucleic acid amplification testing. McNemar's exact tests compared the numbers of HIV-infected subjects detected. Between February 2010 and August 2014, there were 3438 study visits. Twenty-four subjects had discordant POC results with at least one reactive and one non-reactive test, including one subject with a reactive Determine p24 antigen. OraQuick performed on oral fluids identified fewer persons compared to all fingerstick tests. OraQuick performed on fingerstick whole blood detected fewer persons compared to the Determine Combo antibody...Continue Reading

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Citations

Mar 31, 2017·AIDS·Joanne D SteklerRobert W Coombs
May 15, 2018·AIDS Research and Human Retroviruses·Joanne D SteklerAnn C Collier
Apr 27, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·David A KatzJoanne D Stekler
Jan 25, 2020·Sexually Transmitted Diseases·Eugene G MartinGratian Salaru
Oct 3, 2018·Open Forum Infectious Diseases·Joanne D SteklerKevin P Delaney
Jul 28, 2020·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Colleen K GutmanClaudia R Morris
Feb 1, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Xiaoyang LiHongjie Dai
Feb 6, 2020·JMIR Research Protocols·Joanne D SteklerKevin P Delaney
Jun 27, 2018·AIDS and Behavior·Dennis G FisherDavid W Hosmer

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