Performance of existing risk scores in screening for undiagnosed diabetes: an external validation study.

Diabetic Medicine : a Journal of the British Diabetic Association
D R WitteE J Brunner

Abstract

To compare the performance of nine published strategies for the selection of individuals prior to screening for undiagnosed diabetes. We conducted a validation study, based on a cross-sectional analysis of 6990 participants of the Whitehall II study, an occupational cohort of civil servants in London. We calculated sensitivity, specificity and the area under the receiver operating characteristic (ROC) curve, indicative of the ability of a risk score to correctly identify those with undiagnosed diabetes. The prevalence of unknown diabetes was 2.0%. At a set level of sensitivity (0.70), the specificity of the different scores ranged between 0.41 and 0.57. A reference model, based solely on age and body mass index had an area under the ROC curve of 0.67 [95% confidence interval (CI): 0.62, 0.72]. Four scores had a lower area under the ROC curve (lowest ROC AUC: 0.62; 95% CI: 0.58, 0.67) compared with the reference model, while the other five scores had similar areas (highest ROC AUC: 0.68; 95% CI: 0.63, 0.72). All ROC curve areas were lower than those reported in the original publications and validation studies. Existing risk scores for the detection of undiagnosed diabetes perform less well in a large validation cohort compared w...Continue Reading

References

May 6, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·M J DaviesA C Burden
Jun 27, 2000·Diabetes/metabolism Research and Reviews·S J GriffinN J Wareham
Oct 7, 2000·Diabetes Care·M M EngelgauW H Herman
May 29, 2002·Diabetes Care·P J ParkN J Wareham
Mar 1, 2003·Diabetes Care·Jaana Lindström, Jaakko Tuomilehto
Jul 29, 2003·Diabetes Care·Charlotte GlümerUNKNOWN Inter99 study
Sep 25, 2003·Journal of Clinical Epidemiology·S E BleekerK G M Moons
Jan 30, 2004·Diabetes Care·Stephen ColagiuriUNKNOWN AusDiab
Feb 28, 2004·Diabetes Care·Charlotte GlümerUNKNOWN inter99 study
May 22, 2004·American Journal of Infection Control·Georgia P DashUNKNOWN Association for Professionals in Infection Control and Epidemiology
Jan 31, 2006·Diabetes Care·Charlotte GlümerUNKNOWN DETECT-2 Collaboration
Apr 28, 2007·Health Technology Assessment : HTA·N WaughA John
Mar 6, 2008·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Tim A HoltAzeem Majeed
Jul 11, 2008·Diabetes/metabolism Research and Reviews·R D G LeslieP Pozzilli
Feb 26, 2009·Journal of Epidemiology and Community Health·E L Massó GonzálezL A García Rodríguez
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Aug 12, 2009·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN National Institute of Neurological Disorders, National Institutes of Health
Oct 21, 2009·Science & Justice : Journal of the Forensic Science Society·UNKNOWN Association of Forensic Science Providers

❮ Previous
Next ❯

Citations

Nov 23, 2013·Diabetes Research and Clinical Practice·Mohsen JanghorbaniMasoud Amini
May 3, 2014·Diabetes Research and Clinical Practice·L J GrayM J Davies
Mar 12, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·L ChenJ E Shaw
Mar 13, 2012·Diabetes/metabolism Research and Reviews·Thitaporn ThoopputraShu Chuen Li
Jun 18, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·Z C LuoW D Fraser
Mar 31, 2018·International Journal of Environmental Research and Public Health·Andrzej MarcinkiewiczJolanta Walusiak-Skorupa
Jan 13, 2012·PloS One·David Carlton Taylor-RobinsonSimon Capewell
May 1, 2015·Expert Review of Endocrinology & Metabolism·Katya L MasconiAndre Pascal Kengne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.