Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer.

European Radiology
Kazuhiro KitajimaKazuro Sugimura

Abstract

The purpose is to evaluate the accuracy of integrated FDG-PET/CT, compared with PET alone, for diagnosis of suspected recurrence of uterine cervical cancer. Fifty-two women who had undergone treatment for histopathologically proven cervical cancer received PET/CT with suspected recurrence. PET-alone and integrated PET/CT images were evaluated by two different experienced radiologists by consensus for each investigation. A final diagnosis was confirmed by histopathology, radiological imaging, and clinical follow-up for over 1 year. Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET/CT were 92.0% (23/25), 92.6% (25/27), and 92.3% (48/52), respectively, while for PET, the corresponding figures were 80.0% (20/25), 77.8% (21/27), and 78.8% (41/52), respectively. PET/CT resolved the false-positive PET results due to hypermetabolic activity of benign/inflammatory lesions and physiological variants, and was able to detect lung metastasis, local recurrence, peritoneal dissemination, para-aortic lymph node metastasis, and pelvic lymph node metastasis missed by PET alone. However, tiny local recurrence and lymph node metastasis could not be detected even by PET/CT. FDG-PET/CT is a useful complementary mod...Continue Reading

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Citations

Sep 10, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Giovanni Lucignani
Oct 22, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Kazuhiro KitajimaKazuro Sugimura
Jul 9, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Erik MittraAndrei Iagaru
Apr 14, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Kazuhiro KitajimaKazuro Sugimura
Dec 22, 2010·European Radiology·Christiaan Schiepers, Magnus Dahlbom
Sep 17, 2009·Annals of Nuclear Medicine·Kazuhiro KitajimaYuji Nakamoto
Mar 10, 2009·Japanese Journal of Clinical Oncology·Yuji NakamotoMichio Senda
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