Performance of galanin transgenic mice in the 5-choice serial reaction time attentional task

Pharmacology, Biochemistry, and Behavior
Craige C WrennJacqueline N Crawley

Abstract

The neuropeptide galanin impairs learning and memory in rodents. The mechanism underlying the cognitive effects of galanin may be related to inhibitory effects of galanin on cholinergic transmission. As cholinergic function is thought to modulate sustained attention, the present study examined whether galanin-overexpressing transgenic mice have impairments in sustained attention. Galanin transgenic (GAL-tg) mice and wild-type (WT) littermate controls were trained in a 5-choice serial reaction time task, modified to assess sustained attention. GAL-tg and WT mice performed similarly during acquisition with respect to accuracy, total omissions, and response speed. Attentional mechanisms were challenged by parametric changes including increased event rate, event asynchrony, or decreased stimulus duration. Singly, these challenges did not differentially affect performance between genotypes. Concurrent administration of these challenges, which represents an optimal test of sustained attention, also had similar effects on GAL-tg and WT mice. When stimulus discriminability was reduced by constant illumination of the house light, GAL-tg mice omitted more trials than WT mice, but other measures of performance did not differ by genotype. ...Continue Reading

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Citations

May 27, 2008·Cellular and Molecular Life Sciences : CMLS·J N Crawley
Nov 18, 2011·Psychopharmacology·Sandra Sanchez-RoigeDavid N Stephens
Jun 19, 2010·Nature Reviews. Neuroscience·Jill L SilvermanJacqueline N Crawley
Oct 30, 2012·Behavioural Brain Research·Leonardo A OrtegaVinay Parikh
Dec 20, 2007·Journal of Neuroendocrinology·A C AdamsJ R Speakman
Sep 22, 2006·Physiology & Behavior·N M W J de BruinA A H P Megens
Mar 28, 2008·Neuron·Jacqueline N Crawley
Sep 13, 2008·Behavioural Brain Research·Amita KapoorStephen G Matthews
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Jonas FizetHélène Meunier
Feb 25, 2018·Psychiatry Investigation·Tamanna Jahan MonyHee Jae Lee
Jun 11, 2009·Nature Reviews. Neuroscience·Simon P Brooks, Stephen B Dunnett
Nov 11, 2019·Psychopharmacology·F MessanviY Chudasama
Jan 18, 2017·Journal of Psychopharmacology·Maitane Caballero-PuntiverioJesper Tobias Andreasen
Aug 10, 2018·European Journal of Pharmacology·Joshua A BurkEden B Maness

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