Performance of Liaison XL automated immunoassay platform for blood-borne infection screening on hepatitis B, hepatitis C, HIV 1/2, HTLV 1/2 and Treponema pallidum serological markers

Transfusion Medicine
Kerstin MalmSören Andersson

Abstract

Aim of the study was to evaluate performance of a new fully automated platform, DiaSorin-LIAISON® XL (DiaSorin S.p.A, Vercelli, Italy), in blood donor screening, specifically for hepatitis B surface antigen (HBsAg), hepatitis B core antibodies (anti-HBc), hepatitis C antibodies (anti-HCV), HIV p24 antigen, HIV antibodies, human T-lymphotropic virus types 1 and 2 (HTLV-1/2) and Treponema pallidum antibodies. In screening for such viral and bacteriological blood-borne infections, sensitivity and specificity are of utmost importance. Sensitivity was evaluated using selected panels of samples previously analysed on the Abbott Architect immunoanalyser (Abbott Laboratories, Abbott Park, IL, USA)--the gold standard for this evaluation. These samples were confirmed positive for HBsAg, anti-HBc, anti-HCV, HIV Ag/Ab, anti-HTLV-1/2 and antibodies to T. pallidum, respectively. Specificity analysis was assessed by analysing blood donor samples previously run on the Architect platform and found non-reactive for each marker. A total of 1·100 donor samples (both new and regular donors) were tested. Previously, non-specific reactive samples were also run for every tested marker, as well as samples with autoimmune antibodies and antibodies to ot...Continue Reading

References

Nov 1, 1990·Transfusion·A De Schryver, A Meheus
Jul 22, 2010·Journal of Medical Virology·Kerstin MalmSören Andersson
Nov 19, 2010·Bioanalysis·Christophe A Marquette, Loïc J Blum
May 24, 2013·Clinical and Vaccine Immunology : CVI·Antonella MarangoniRoberto Cevenini
Nov 26, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Adalbert KrawczykMelanie Fiedler
Jun 27, 2014·Journal of Clinical Microbiology·Véronique LemeeJean-Christophe Plantier
Aug 26, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Enza Renata FrutteroJessica Antonella De Matteis

❮ Previous
Next ❯

Citations

Apr 13, 2017·Journal of Medical Virology·Massimo De PaschalePierangelo Clerici
Nov 23, 2017·PloS One·Ahmad FarooqMuhammad Arshad
Aug 29, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Le ChangLunan Wang
Sep 21, 2018·Journal of Clinical Microbiology·Vanessa da Silva BritoBernardo Galvão-Castro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Adalbert KrawczykMelanie Fiedler
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
F RenH Zhao
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Tonya Mixson-HaydenSaleem Kamili
© 2021 Meta ULC. All rights reserved