Performance of monolayered cervical smears in a gynecology outpatient setting in Kuwait

Acta Cytologica
Usha K LuthraShaheed Khan

Abstract

To compare ThinPrep (TP) Papanicolaou smears (Cytyc Corp., Box-borough, Massachusetts, U.S.A.) with matching conventional Papanicolaou (CP) smears for specimen adequacy, cytologic quality, diagnostic accuracy and screening time. In this prospective study of 1,024 women a split-sample, matched-pair design in favor of CP slides based on single-blind criteria was followed with a smear on a glass slide for CP and the remaining material collected in Preserv-Cyt solution (Cytyc) for a TP smear. A Cytobrush (Medscand, Hollywood, Florida, U.S.A.) was used for smear preparation for CP. TP smears were processed in ThinPrep 2000 (Cytyc). Smears were stained with Papanicolaou stain and were interpreted according to the Bethesda system. The number of satisfactory but limited (SBL) cases with TP were 77 (7.5%) as compared to 127 (12.4%) with the CP method. This reduction in SBL smears with the TP method and consequent increase in satisfactory smears were highly significant (P < .001) by McNemar's test. As regards unsatisfactory smears in discordant pairs, although the number of unsatisfactory smears was higher with TP (41 cases) as against CP (27 cases), the difference was not statistically significant (P < .05). The split-sample method show...Continue Reading

Citations

Jun 10, 2006·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Kusum KapilaIssam M Francis
Jan 11, 2007·CytoJournal·Pranab Dey
Sep 27, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·SuFang WuDing Ma
Oct 12, 2011·Diagnostic Cytopathology·Rana Al-AwadhiKusum Kapila
Dec 3, 2009·Journal of Women's Health·Khadija El-HammasiLukman Thalib
Sep 27, 2003·Cytopathology : Official Journal of the British Society for Clinical Cytology·M S Wachtel, P F Dahm
Jan 26, 2011·Journal of Medical Virology·Rana Al-AwadhiKusum Kapila

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