Performance of OCT segmentation procedures to assess morphology and extension in geographic atrophy

Acta Ophthalmologica
Christopher SchützeUrsula Schmidt-Erfurth

Abstract

Investigating segmentation procedures and morphological findings in time domain (TD) and current spectral domain (SD) optical coherence tomography (OCT) devices in patients with geographic atrophy (GA). Fifty eyes of 46 patients with GA secondary to AMD and 15 control eyes were examined in this prospective noninterventional comparative case series. All patients underwent Stratus (model 3000), Cirrus (Carl Zeiss Meditec), Spectralis (Spectralis HRA+OCT; Heidelberg Engineering) and 3D-OCT-1000 (Topcon). Automated segmentation analyses were compared. An overlay of scanning laser ophthalmoscope (SLO) and three-dimensional retinal thickness (RT) maps were used to investigate whether areas of retinal thinning correspond to areas of retinal pigment epithelium (RPE) atrophy. Geographic atrophy areas identified in SLO scans were significantly larger than areas of retinal thinning in RT maps. No convincing topographic correlation could be found between areas of retinal thinning and actual GA size as identified in SLO and fundus photography. Spectralis OCT showed significantly more mild and severe segmentation errors than 3D and Cirrus OCT. This study showed substantial limitations in identifying zones of GA reliably when using automatic ...Continue Reading

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Citations

Jul 28, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Grant D AakerSzilárd Kiss
Aug 18, 2012·Survey of Ophthalmology·Pearse A KeaneAdnan Tufail
Mar 21, 2013·Ophthalmic Surgery, Lasers & Imaging Retina·Zohar YehoshuaPhilip J Rosenfeld
Feb 16, 2013·Ophthalmic Surgery, Lasers & Imaging Retina·Fernando M PenhaPhilip J Rosenfeld
Mar 10, 2016·Ophthalmology·Karen B SchaalWilliam J Feuer
Nov 23, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Julien TilleulEric H Souied
Jan 11, 2014·Biomedical Optics Express·Qiang ChenDaniel L Rubin
Apr 12, 2020·American Journal of Ophthalmology·Ursula Schmidt-ErfurthGregor S Reiter

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