Performance of pfHRP2 versus pLDH antigen rapid diagnostic tests for the detection of Plasmodium falciparum: a systematic review and meta-analysis

Archives of Medical Science : AMS
Bo LiYuanli Mao

Abstract

There have been many inconsistent reports about the performance of histidine-rich protein 2 (HRP2) and lactate dehydrogenase (LDH) antigens as rapid diagnostic tests (RDTs) for the diagnosis of past Plasmodium falciparum infections. This meta-analysis was performed to determine the performance of pfHRP2 versus pLDH antigen RDTs in the detection of P. falciparum. After a systematic review of related studies, Meta-DiSc 1.4 software was used to calculate the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Forest plots and summary receiver operating characteristic curve (SROC) analysis were used to summarize the overall test performance. Fourteen studies which met the inclusion criteria were included in the meta-analysis. The summary performances for pfHRP2- and pLDH-based tests in the diagnosis of P. falciparum infections were as follows: pooled sensitivity, 96.3% (95.8-96.7%) vs. 82.6% (81.7-83.5%); specificity, 86.1% (85.3-86.8%) vs. 95.9% (95.4-96.3%); diagnostic odds ratio (DOR), 243.31 (97.679-606.08) vs. 230.59 (114.98-462.42); and area under ROCs, 0.9822 versus 0.9849 (all p < 0.001). The two RDTs performed satisfactorily for the diagnosis o...Continue Reading

Citations

Aug 11, 2020·Expert Review of Anti-infective Therapy·Rosauro VaroQuique Bassat
Nov 8, 2018·Parasitology Research·José Antonio Garrido-CardenasConcepción Mesa-Valle
Apr 10, 2019·PloS One·Diego F JosephPohl Milón
Feb 7, 2020·Sensors·Francis D KrampaGordon A Awandare
Dec 19, 2019·Trends in Parasitology·Kristin E PotiCharles J Woodrow
Mar 21, 2021·Diagnostic Microbiology and Infectious Disease·Junjun HuXin Liu

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Methods Mentioned

BETA
while

Software Mentioned

Meta
Review Manager ( RevMan )
DiSc
RevMan
QUADAS
Quality Assessment of Diagnostic Accuracy Studies ( QUADAS - 2 )

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