Performance of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting

The American Journal of Clinical Nutrition
Øivind MidttunPer M Ueland

Abstract

Coffee is a widely consumed beverage, and studies suggest that drinking coffee has beneficial health effects. The phytohormone trigonelline is present in large amounts in coffee beans, and circulating concentrations of trigonelline have been shown to be positively related to dietary intake of coffee and to increase significantly after the consumption of a bolus dose of coffee. We cross-sectionally investigated the utility of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting. We secondarily investigated if coffee intake is related to plasma concentrations of vitamin B-3 (niacin) forms. In a Norwegian cohort of 3503 participants, we combined questionnaire data on the number of cups of coffee consumed per day with plasma trigonelline to evaluate trigonelline as a marker of coffee intake. The suitability of plasma trigonelline to discriminate those not consuming from those consuming coffee was investigated by receiver operating characteristic (ROC) analysis. Plasma collected at 2 time points 1 y apart was used to determine the within-person reproducibility of trigonelline. We found that plasma trigonelline concentrations increased strongly with increasing amounts of coffee consumed. ROC analysis show...Continue Reading

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Citations

Sep 5, 2019·Molecular Nutrition & Food Research·Joseph A RothwellAugustin Scalbert
Jun 21, 2019·Molecular Nutrition & Food Research·Dorrain Yanwen LowClaudine Manach
Sep 22, 2020·Nature Food·Joram M PosmaJeremy K Nicholson
Jan 12, 2021·Metabolomics : Official Journal of the Metabolomic Society·Yuko YamaguchiRichard D Semba
Dec 31, 2020·International Journal of Molecular Sciences·Katarzyna SocałaPiotr Wlaź
Jan 31, 2021·Metabolomics : Official Journal of the Metabolomic Society·Tiina JääskeläinenHannele Laivuori
Apr 23, 2021·Genes & Nutrition·Katherine J LiEdith J M Feskens
Jun 13, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Pierre-Antoine DuguéGraham G Giles

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