Performance of rapid diagnostic tests for the detection of antibodies to hepatitis C virus in whole blood collected on dried blood spots

Journal of Viral Hepatitis
Lila PoiteauStéphane Chevaliez

Abstract

Rapid diagnostic tests (RDTs) represent an attractive alternative to enzyme immunoassays. A total of 207 individuals, including 68 HCV-seronegative subjects, 10 patients with resolved infection and 129 patients with chronic HCV infection, were studied. The specificity of RDT detection of anti-HCV antibodies in whole blood was 100% with the four RDTs tested: OraQuick(®) HCV Rapid Antibody Test, First Response HCV Card Test, ASSURE HCV Rapid Test and MultiSure HCV Antibody Assay. Their diagnostic sensitivity varied between 98.6% and 100%. RDT detection of anti-HCV antibody in whole blood collected on dried blood spots appears to be a promising new tool for broadscale screening of HCV infection in high- to medium-risk populations.

References

Sep 22, 2011·Journal of Viral Hepatitis·A HatzakisH L A Janssen
Jan 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maxine M DennistonRuth B Jiles
Oct 17, 2012·Annals of Internal Medicine·Sushmita ShivkumarNitika Pant Pai
Sep 4, 2015·The Journal of Infectious Diseases·Alexandre SoulierStéphane Chevaliez

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Citations

Sep 27, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Nov 2, 2017·Expert Review of Molecular Diagnostics·Jason GrebelyJordan J Feld
May 19, 2018·Nature Reviews. Gastroenterology & Hepatology·Marianne MartinelloGail V Matthews
Aug 30, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Emma DayUNKNOWN International Network on Hepatitis in Substance Users (INHSU)
Dec 26, 2018·Expert Review of Anti-infective Therapy·Mauro ViganòAnna Linda Zignego
Oct 12, 2018·Viruses·Pierre PradatEric Trépo
Dec 10, 2019·Enfermedades infecciosas y microbiología clínica·Lorena GómezManuel Hernández-Guerra
May 12, 2020·Gastroenterology Clinics of North America·Marianne MartinelloGregory J Dore
Sep 22, 2020·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.euUNKNOWN Panel members:

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