Performance of response criteria for assessing peripheral arthritis in patients with psoriatic arthritis: analysis of data from randomised controlled trials of two tumour necrosis factor inhibitors.

Annals of the Rheumatic Diseases
J FransenP L C M Van Riel

Abstract

In recent clinical trials in patients with psoriatic arthritis (PsA), the response criteria and disease activity measures that have been used were those developed for rheumatoid arthritis. However, these have not yet been validated in PsA. To compare the responsiveness and discriminative capacity of the psoriatic arthritis response criteria (PsARC), American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) response criteria and the Disease Activity Score (DAS) and core-set measures in patients with PsA and peripheral arthritis, using the data from two randomised placebo-controlled trials of tumour necrosis factor inhibitors. In an infliximab trial, 104 patients with active PsA were randomised to receive placebo or infliximab for 16 weeks. In an etanercept trial, 60 patients with active PsA were randomised to receive placebo or etanercept for 12 weeks. Data from baseline and the end of the intervention phase were used from each study. Responsiveness was assessed using the standardised response mean and effect size. Capacity to discriminate between the active drug and placebo was assessed using t values or a chi2 test. Measures were ranked in order of their t value or chi2 value. The EULAR criteria per...Continue Reading

References

Aug 1, 1991·British Journal of Rheumatology·J C Torre AlonsoC Lopez Larrea
Oct 1, 1991·British Journal of Rheumatology·P HelliwellV Wright
Oct 20, 1998·Arthritis and Rheumatism·A M van GestelP L van Riel
Nov 23, 2000·Annals of the Rheumatic Diseases·A C VerhoevenS van Der Linden
Jan 20, 2004·Arthritis and Rheumatism·Dafna D GladmanWilliam Taylor
Feb 15, 2005·Annals of the Rheumatic Diseases·P J MeaseW J Taylor
May 28, 2005·Current Rheumatology Reports·Arthur Kavanaugh, Sarah Cassell

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Citations

Oct 7, 2009·Nature Reviews. Rheumatology·Astrid M van Tubergen, Robert B M Landewé
Sep 14, 2011·Nature Reviews. Rheumatology·Caroline A ChangPaul F Lizzul
Apr 9, 2013·Annals of the Rheumatic Diseases·Karen Minde FagerliTore K Kvien
Oct 28, 2008·Annals of the Rheumatic Diseases·C T RitchlinUNKNOWN Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)
Feb 1, 2011·Therapeutic Advances in Musculoskeletal Disease·Tajvur P SaberDouglas J Veale
Mar 29, 2014·Actas dermo-sifiliográficas·A López-Ferrer, A Laiz-Alonso
Dec 10, 2014·Best Practice & Research. Clinical Rheumatology·Pedro M Machado, Siba P Raychaudhuri
Jul 30, 2008·Current Rheumatology Reports·Kurt de Vlam, Rik J U Lories
Sep 24, 2009·Current Rheumatology Reports·Robert B M Landewé, Astrid van Tubergen
May 4, 2010·Current Rheumatology Reports·Vinod Chandran, Dafna D Gladman
Dec 1, 2011·Wiener klinische Wochenschrift·Simeon GrazioZvonko Kusić
Aug 5, 2014·Expert Review of Clinical Immunology·Minyoung Her, Arthur Kavanaugh
Nov 13, 2015·Expert Review of Clinical Immunology·Francesco CasoLuisa Costa
Jan 7, 2011·Expert Opinion on Drug Safety·Amr A SaadDarren M Ashcroft
Jan 26, 2016·Expert Review of Clinical Immunology·V Chandran, A B Maharaj
Aug 8, 2012·Best Practice & Research. Clinical Rheumatology·Keegan KnittleStan Maes
Jul 29, 2011·Reumatología clinica·Jose Luis Fernández SueiroUNKNOWN Sociedad Española de Reumatología [Spanish Society of Rheumatology]
Oct 18, 2015·Rheumatic Diseases Clinics of North America·Laura Coates
Sep 2, 2008·Arthritis and Rheumatism·Lai-Shan TamCheuk-Man Yu
Apr 14, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·P LawsR B Warren
May 3, 2016·Rheumatic Diseases Clinics of North America·Ana-Maria Orbai, Alexis Ogdie
Jul 1, 2010·Arthritis Care & Research·Laura C Coates, Philip S Helliwell
Jun 19, 2013·Journal of Advanced Nursing·Ingrid LarssonStefan Bergman
Sep 21, 2012·Scandinavian Journal of Rheumatology·F IannoneG Lapadula
Aug 14, 2015·Annals of the Rheumatic Diseases·Monika M SchoelsJosef S Smolen

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