Performance of rotavirus vaccines in developed and developing countries.

Human Vaccines
Victoria JiangManish M Patel

Abstract

The World Health Organization estimates that rotavirus diarrhea results in approximately half a million deaths and approximately 2.4 million hospitalizations in developing countries each year. Two live oral rotavirus vaccines, RotaTeq® (RV 5; Merck) and Rotarix® (RV 1; GlaxoSmithKline) with good efficacy against severe rotavirus disease and a reassuring safety profile could substantially impact the burden of rotavirus disease. In April 2009, WHO provided a recommendation for global introduction of these vaccines in national immunization programs of developing countries worldwide. In this article, we review published data on previous candidate rotavirus vaccines and vaccines in current use, with emphasis on their performance in developed versus developing countries. In developed countries, both first and second generation rotavirus vaccines have demonstrated high efficacy against severe rotavirus disease (pooled efficacy = 73% and 85%, respectively). In developing countries, small early trials for the first generation vaccines failed to provide protection against rotavirus disease (pooled efficacy = 20%), however, trials of the second generation vaccines yielded substantial improvements in efficacy in developing countries (poole...Continue Reading

References

Sep 1, 1991·Reviews of Infectious Diseases·P A PatriarcaT J John
Feb 1, 1991·Acta paediatrica Scandinavica·T VesikariT H Flewett
Mar 1, 1991·The Journal of Infectious Diseases·M SantoshamA Z Kapikian
Jan 1, 1990·Scandinavian Journal of Infectious Diseases·T Ruuska, T Vesikari
Sep 1, 1988·The Pediatric Infectious Disease Journal·C ChristyR Dolin
Jul 12, 1986·Lancet·P De MolF E André
Feb 1, 1980·Journal of Clinical Microbiology·G StukerN J Schmidt
Apr 1, 1995·The Pediatric Infectious Disease Journal·J J TreanorP Offit
Aug 1, 1993·The Journal of Infectious Diseases·M K BhanR I Glass
Dec 1, 1995·Journal of Medical Virology·A M RojasI Pérez-Schael
Sep 1, 1996·The Journal of Infectious Diseases·H F ClarkS A Plotkin
Oct 3, 1996·The New England Journal of Medicine·F R VelázquezG M Ruiz-Palacios
Jul 1, 1996·Clinical Microbiology Reviews·K Midthun, A Z Kapikian
Oct 23, 1997·The New England Journal of Medicine·I Pérez-SchaelA Z Kapikian
Feb 24, 2001·The New England Journal of Medicine·T V MurphyUNKNOWN Rotavirus Intussusception Investigation Team
May 10, 2003·Emerging Infectious Diseases·Umesh D ParasharRoger I Glass
Dec 17, 2004·The Pediatric Infectious Disease Journal·Timo VesikariBeatrice De Vos
Aug 10, 2005·The Journal of Infectious Diseases·Roger I GlassA Duncan Steele
Nov 12, 2005·The Pediatric Infectious Disease Journal·Joseph S BreseeRoger I Glass
Jan 6, 2006·The New England Journal of Medicine·Guillermo M Ruiz-PalaciosUNKNOWN Human Rotavirus Vaccine Study Group
Jan 6, 2006·The New England Journal of Medicine·Timo VesikariUNKNOWN Rotavirus Efficacy and Safety Trial (REST) Study Team
Feb 1, 2006·Vaccine·Manuel A FrancoHarry B Greenberg
Feb 10, 2006·Pediatric Annals·David I Bernstein, Richard L Ward

❮ Previous
Next ❯

Citations

Jun 1, 2011·Indian Journal of Virology : an Official Organ of Indian Virological Society·Anupam Mukherjee, Mamta Chawla-Sarkar
Oct 26, 2013·The Journal of Infection·Roger I GlassBaoming Jiang
Aug 26, 2011·The New England Journal of Medicine·Vesta RichardsonManish Patel
Mar 1, 2013·Journal of the Pediatric Infectious Diseases Society·Edgar Sánchez-UribeVesta Richardson
Sep 7, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John Clemens
Dec 15, 2010·MBio·Joseph M HyserMary K Estes
Oct 1, 2011·Future Microbiology·Souvik Ghosh, Nobumichi Kobayashi
Aug 2, 2011·Emerging Infectious Diseases·Stephan S Monroe
Mar 14, 2014·Bulletin of the World Health Organization·Marcelino Esparza-AguilarManish Patel
Feb 13, 2015·Virusdisease·Souvik Ghosh, Nobumichi Kobayashi
Oct 1, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A-L DelteilT Lamireau
Aug 13, 2014·Trends in Immunology·Yanet ValdezB Brett Finlay
Dec 15, 2015·Revista Argentina de microbiología·Lucia MaffeyLorena Garaicoechea
Oct 22, 2013·Enfermedades infecciosas y microbiología clínica·Alicia Sánchez-FauquierIsabel Wilhelmi-De Cal
Jun 30, 2012·The Lancet Infectious Diseases·Manish M PatelUmesh D Parashar
Sep 10, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Devy M EmperadorKhalequ Zaman
Mar 20, 2016·Current Opinion in Biotechnology·Andrew B HillCharles H Jones
Oct 23, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mokibul Hassan AfradMustafizur Rahman
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul A GastañaduyJohn P McCracken
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura K BeresRoma Chilengi
Apr 8, 2015·Vaccine·O Badillo-GodinezF Esquivel-Guadarrama
Dec 3, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Prasanna S PremkumarBen A Lopman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.