Performance of serum apolipoprotein-A1 as a sentinel of Covid-19

PloS One
Thierry PoynardP. Cacoub

Abstract

Since 1920, a decrease in serum cholesterol has been identified as a marker of severe pneumonia. We have assessed the performance of serum apolipoprotein-A1, the main transporter of HDL-cholesterol, to identify the early spread of coronavirus disease 2019 (Covid-19) in the general population and its diagnostic performance for the Covid-19. We compared the daily mean serum apolipoprotein-A1 during the first 34 weeks of 2020 in a population that is routinely followed for a risk of liver fibrosis risk in the USA (212,297 serum) and in France (20,652 serum) in relation to a local increase in confirmed cases, and in comparison to the same period in 2019 (266,976 and 28,452 serum, respectively). We prospectively assessed the sensitivity of this marker in an observational study of 136 consecutive hospitalized cases and retrospectively evaluated its specificity in 7,481 controls representing the general population. The mean serum apolipoprotein-A1 levels in the survey populations began decreasing in January 2020, compared to the same period in 2019. This decrease was highly correlated with the daily increase in confirmed Covid-19 cases in the following 34 weeks, both in France and USA, including the June and mid-July recovery periods i...Continue Reading

Associated Clinical Trials

References

Apr 16, 2011·BMC Gastroenterology·Thierry PoynardFrançoise Imbert-Bismut
Dec 30, 2017·PloS One·Valentina PetaUNKNOWN Drug Induced Liver Group of the Injury Safer and Faster Evidence-based Translation consortium
Jan 23, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rachel J ChurchPaul B Watkins
Feb 26, 2020·International Journal of Oral Science·Hao XuQianming Chen
Feb 29, 2020·The New England Journal of Medicine·Bill Gates
Mar 8, 2020·The Lancet. Gastroenterology & Hepatology·Chao ZhangFu-Sheng Wang
Apr 9, 2020·BMJ : British Medical Journal·Laure WynantsMaarten van Smeden
May 3, 2020·Science·Mart M LamersHans Clevers
May 15, 2020·Science·Henrik SaljeSimon Cauchemez
May 21, 2020·Journal of Clinical Lipidology·Xiuqi WeiHui Wang
Jun 6, 2020·American Journal of Physiology. Endocrinology and Metabolism·Xiaoling CaoWenbin Tan

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Citations

Jul 6, 2021·Hepatology Communications·Miguel Angel Martinez, Sandra Franco

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT01927133

Software Mentioned

SAFET
NASH
FibroTest

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