Performance of TB immunodiagnostic tests in Eurasian badgers (Meles meles) of different ages and the influence of duration of infection on serological sensitivity.

BMC Veterinary Research
Mark A ChambersR Glyn Hewinson

Abstract

In parts of Great Britain and Ireland, Eurasian badgers (Meles meles) constitute a reservoir of Mycobacterium bovis infection and a potential source of infection for cattle. In vitro diagnostic tests for live badgers are an important component of strategies to control TB in this species. Immunological tests have been developed for badgers, although little is known about the influence of the age of the animal on test performance. To address this, we evaluated the performance of three immunological tests for badgers with respect to the age of the animal: the Brock Test and BrockTB STAT-PAK serological tests and the recently developed interferon-gamma enzyme immunoassay (IFNgamma EIA). Data published elsewhere suggested that seropositivity was associated with more progressive forms of TB in the badger. To gain further evidence for this, we used longitudinal data from a well-studied population of badgers to test for an association between the sensitivity of the Brock Test and the duration of TB infection. Sensitivity of the two serological tests was approximately 54% for both cubs and adults. Sensitivity of the IFNgamma EIA was lower in cubs (57%) compared with adults (85%) when a common cut-off value was used to define test positi...Continue Reading

References

Nov 25, 1995·The Veterinary Record·R S Clifton-HadleyM P Stock
Mar 20, 2002·Veterinary Microbiology·M A ChambersR G Hewinson
Jul 18, 2003·Diagnostic Microbiology and Infectious Disease·Rena GreenwaldKonstantin Lyashchenko
Mar 8, 2005·Preventive Veterinary Medicine·J M GriffinS J More
Nov 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·D R CoxRosie Woodroffe
Jun 15, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Christl A DonnellyW Ivan Morrison

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Citations

Mar 26, 2013·Epidemiology and Infection·A J TomlinsonR J Delahay
Feb 19, 2016·Proceedings. Biological Sciences·Christopher BeirneAndrew Young
Jun 26, 2018·The Journal of Animal Ecology·Clare H BentonDave Hodgson
Jun 5, 2015·Journal of Clinical Microbiology·Hayley C KingElizabeth M Wellington
Dec 22, 2017·Ecology Letters·Matthew J SilkRobbie A McDonald
Jan 1, 2013·Behavioral Ecology and Sociobiology·Nicola WeberStephen P Carter
Jun 6, 2018·Frontiers in Veterinary Science·Jenni L McDonald, Dave James Hodgson
Oct 16, 2020·Journal of Clinical Microbiology·Andrew R J MurphyElizabeth M H Wellington
Feb 26, 2021·Veterinary Research·Jobin ThomasMaría A Risalde

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Methods Mentioned

BETA
ELISA
Culling

Software Mentioned

GraphPad InStat
STATA
Analyse
it
STAT

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