Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis

PLoS Medicine
Benedikt LeyRic N Price


To reduce the risk of drug-induced haemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria. This systematic review and individual patient meta-analysis assessed the utility of a qualitative lateral flow assay from Access Bio/CareStart (Somerset, NJ) (CareStart Screening test for G6PD deficiency) for the diagnosis of G6PDd compared to the gold standard spectrophotometry (International Prospective Register of Systematic Reviews [PROSPERO]: CRD42019110994). Articles published on PubMed between 1 January 2011 and 27 September 2019 were screened. Articles reporting performance of the standard CSG from venous or capillary blood samples collected prospectively and considering spectrophotometry as gold standard (using kits from Trinity Biotech PLC, Wicklow, Ireland) were included. Authors of articles fulfilling the inclusion criteria were contacted to contribute anonymized individual data. Minimal data requested were sex of the participant, CSG result, spectrophotometry result in U/gHb, and haemoglobin (Hb) reading. The adjusted male median (AMM) was calculated per site and defined as 100% G6PD ac...Continue Reading


Sep 6, 2002·Journal of General Internal Medicine·Steven McGee
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Kevin Baird, Stephen L Hoffman
Mar 21, 2007·Nature Reviews. Microbiology·Shabir BanooUNKNOWN TDR Diagnostics Evaluation Expert Panel
Sep 26, 2008·Statistics in Medicine·Richard D RileyPaula R Williamson
May 20, 2009·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Kenneth J Drobatz
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Feb 2, 2012·Blood Cells, Molecules & Diseases·Angelo MinucciEttore Capoluongo
Aug 21, 2012·Malaria Journal·George K JohnRic N Price
Apr 30, 2014·The American Journal of Tropical Medicine and Hygiene·Michael E von FrickenBernard A Okech
Sep 10, 2014·BMC Medical Genetics·Shivang S ShahThomas N Williams
Nov 5, 2014·Malaria Journal·Elizabeth A AshleyNicholas J White
Sep 30, 2015·Malaria Journal·Benedikt LeyGonzalo J Domingo
Feb 20, 2016·PLoS Neglected Tropical Diseases·Ari W SatyagrahaJ Kevin Baird
Aug 17, 2016·Drug Design, Development and Therapy·Yehenew A EbstieDawit A Ejigu
Sep 7, 2016·Revista Da Sociedade Brasileira De Medicina Tropical·Marcelo Augusto Mota BritoMarcus Vinícius Guimarães de Lacerda
Nov 4, 2016·The American Journal of Tropical Medicine and Hygiene·Michelle E RohSunil Parikh
Dec 13, 2016·International Journal of Molecular Sciences·Saúl Gómez-ManzoRoberto Arreguin-Espinosa
Sep 13, 2017·Malaria Journal·Benedikt LeyRic N Price
Mar 4, 2018·Malaria Journal·Cindy S ChuLucio Luzzatto

❮ Previous
Next ❯


Jul 14, 2020·British Journal of Clinical Pharmacology·Borimas Hanboonkunupakarn, Nicholas J White
Jan 24, 2020·Malaria Journal·Tobias BrummaierRose McGready
May 15, 2020·Trends in Parasitology·Ric N PriceKamini Mendis
Apr 2, 2021·Frontiers in Pharmacology·Germana Bancone, Cindy S Chu
Apr 24, 2021·PLoS Medicine·Kamala ThriemerLorenz von Seidlein
Aug 13, 2021·PLoS Neglected Tropical Diseases·Stephanie ZobristMarcus Vg Lacerda

❮ Previous
Next ❯

Software Mentioned

Access Bio

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.