Performance of the Atlas Genetics Rapid Test for Chlamydia trachomatis and Women's Attitudes Toward Point-Of-Care Testing

Sexually Transmitted Diseases
Lea E WiddiceCharlotte A Gaydos

Abstract

This study compared performance of the Atlas io polymerase chain reaction-based, point-of-care (POC) assay for Chlamydia trachomatis (CT), to Aptima Combo 2, a standard of care nucleic acid amplification assay, and evaluated patient attitudes toward POC testing. Women 14 years or older undergoing CT screening/testing were recruited from Teen Health Center and a sexually transmitted disease clinic. Participants provided self-obtained vaginal swabs for testing with the Atlas io and Aptima Combo 2, and completed questionnaires assessing attitudes toward POC testing. Of 296 women recruited, 284 (192 from sexually transmitted disease clinic, 92 from Teen Health Center) had Aptima Combo 2 and Atlas io results available; 273 completed the questionnaire. Average age was 27.4 years (SD, 10.8 years). Sensitivity and specificity of the Atlas io test were 83.9% (26/31 specimens; 95% confidence interval [CI], 70.9-96.8%) and 98.8% (250/253 specimens; 95% CI, 97.5-100%), respectively. When specimens with discrepant results were included in the analyses, adjudicated sensitivity and specificity were 92.9% (26/28 specimens; 95% CI, 83.3 to 100%) and 98.8% (253/256 specimens; 95% CI, 97.5 to 100%), respectively.A majority (70%) of women preferre...Continue Reading

References

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Mar 9, 2013·Sexually Transmitted Infections·Jill S HuppertJennifer L Reed
Oct 29, 2013·Sexual Health·Anne M RompaloCharlotte A Gaydos
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Citations

Aug 31, 2019·Journal of the International AIDS Society·Teodora Ec WiMagnus Unemo
Nov 7, 2019·Sexually Transmitted Diseases·Jesse GettingerBarbara Van Der Pol
Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Minttu M RönnJoshua A Salomon
Jun 6, 2020·Expert Review of Molecular Diagnostics·Charlotte A Gaydos, Johan H Melendez
Dec 20, 2019·Sexually Transmitted Diseases·Jesse GettingerBarbara Van Der Pol
Aug 19, 2020·Archives of Pathology & Laboratory Medicine·Paul C AdamsonJeffrey D Klausner
May 14, 2021·Science Translational Medicine·Alexander Y TrickTza-Huei Wang
Jul 7, 2021·Expert Review of Molecular Diagnostics·Barbara Van Der Pol, Charlotte A Gaydos
Jun 11, 2021·Sexually Transmitted Diseases·Charlotte A GaydosJohan H Melendez

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