Performance of the BD-FACS Presto for CD4 count and hemoglobin measurement in a district hospital and rural laboratory in Ghana

PloS One
Zelda MoranYanis Ben Amor

Abstract

In Ghana, initiation of Antiretroviral Therapy (ART) is recommended for all patients with an HIV diagnosis, regardless of CD4+ T-cell count. However, measurement of CD4 count remains an important metric for identifying patients with advanced HIV disease, and assessing a person's overall immune status, which informs the decision to offer opportunistic infection screening and prophylaxis. Access to CD4+ T cell count in rural health facilities remains a major challenge in Ghana and other resource-limited settings. This study aimed to validate the accuracy of the BD FACSPresto near-patient device for measurement of CD4 count and hemoglobin concentration against the FACSCount (CD4) and Sysmex (hemoglobin) diagnostic machines when operated in both a district hospital and rural laboratory, serving a network of health posts in Ashanti Region, Ghana. In the first phase of the study, patients were recruited from a district hospital, and both venous and capillary blood samples were tested using the FACSCount and Sysmex as reference tests and compared to results of the FACSPresto performed in the clinic laboratory at the district hospital. In the second phase, patients were recruited from both the hospital and from rural health clinics, an...Continue Reading

References

Jun 3, 2014·BMC Public Health·Osita Kingsley EzehAndrew Nicholas Page
Jan 7, 2017·Current Opinion in HIV and AIDS·Nathan FordTom Chiller
Jul 21, 2017·The New England Journal of Medicine·James HakimUNKNOWN REALITY Trial Team
Mar 8, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alexandra CalmyGraeme Meintjes
May 12, 2018·International Journal of STD & AIDS·Willem Daniel Francois VenterDeborah K Glencross
Jan 5, 2019·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·K AndersonM-A Davies

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Citations

Oct 15, 2020·Archives of Pathology & Laboratory Medicine·Hyung-Doo Park

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Methods Mentioned

BETA
blood draw

Software Mentioned

FACSCalibur
Excel
SAS
Presto
FACSCount
GraphPad Prism

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