Performance of the postwash total motile sperm count as a predictor of pregnancy at the time of intrauterine insemination: a meta-analysis

Fertility and Sterility
Janne-Meije van WeertB W J Mol

Abstract

To assess the performance and clinical value of the postwash total motile sperm count (postwash TMC) as a test to predict intrauterine insemination (IUI) outcome. Meta-analysis of diagnostic tests. Tertiary fertility center. Patients undergoing IUI. None. We detected 16 studies that reported on postwash TMC at insemination and IUI outcome. Summary receiver operating characteristics (ROC) curves indicated a reasonable predictive performance toward IUI outcome, and, at cut-off levels between 0.8 to 5 million motile spermatozoa, the postwash TMC provided a substantial discriminative performance. At these cut-off levels, the specificity of the postwash TMC, defined as the ability to predict failure to become pregnant, was as high as 100%; the sensitivity of the test, defined as the ability to predict pregnancy, was limited. The postwash TMC at insemination could potentially be used in counseling patients for either IUI or IVF. However, to enable patient counseling before the start of treatment, further studies are needed to establish the accuracy of a postwash TMC during the fertility workup rather than at insemination.

References

Apr 15, 1994·Annals of Internal Medicine·L IrwigF Mosteller
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 30, 1999·Human Reproduction·S Nuojua-HuttunenH Martikainen
Jun 16, 1999·American Journal of Obstetrics and Gynecology·B A StoneR P Marrs
Sep 24, 1999·JAMA : the Journal of the American Medical Association·J G LijmerP M Bossuyt
Feb 13, 2001·Acta Obstetricia Et Gynecologica Scandinavica·M R KhalilL G Westergaard
Sep 25, 2002·International Journal of Andrology·Robert Kuo-Kuang LeeJin-Tsung Su

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Citations

Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·A Amar-HoffetJ Belaisch-Allart
Jun 1, 2006·Current Opinion in Obstetrics & Gynecology·Herman Tournaye
Oct 24, 2013·Reproductive Biology and Endocrinology : RB&E·Lígia F P de AraújoAnaglória Pontes
Dec 20, 2011·Asian Journal of Andrology·Herman Tournaye
Jul 19, 2013·Human Fertility : Journal of the British Fertility Society·Mathew TomlinsonUNKNOWN British Fertility Society
Jun 19, 2012·Best Practice & Research. Clinical Obstetrics & Gynaecology·Herman J Tournaye, Ben J Cohlen
Jan 18, 2006·Reproductive Biomedicine Online·Janne-Meije van WeertBen Willem J Mol
Mar 2, 2016·Fertility and Sterility·Louise LemmensUNKNOWN Semen Section of the Dutch Foundation for Quality Assessment in Medical Laboratories
Jun 14, 2008·The Journal of Urology·Moshe Wald
Apr 22, 2008·The Urologic Clinics of North America·Brian A Levine, Jamie A Grifo
Apr 11, 2008·International Journal of Andrology·Thomas FreourPaul Barriere
Dec 24, 2013·Human Fertility : Journal of the British Fertility Society·Chey G DearingKevin S Lindsay
Jan 25, 2014·Reproductive Biomedicine Online·Willem OmbeletThinus Kruger
Feb 17, 2018·Human Reproduction Update·Ben CohlenWillem Ombelet
May 19, 2016·American Journal of Men's Health·Roshanak AboutorabiFatemeh Sadat Mostafavi
Nov 1, 2013·The Cochrane Database of Systematic Reviews·Astrid E P CantineauCindy Farquhar
Jul 3, 2020·Human Reproduction·I de NieN M van Mello
Feb 27, 2016·The Cochrane Database of Systematic Reviews·Maartje CissenMadelon van Wely
May 8, 2020·High-throughput·Rossella TomaiuoloValeria D'Argenio
Aug 18, 2020·Journal of Assisted Reproduction and Genetics·Alessandra J AinsworthZaraq Khan
Feb 24, 2006·Current Opinion in Obstetrics & Gynecology·Chyong-Huey Lai, Huei-Jean Huang
Apr 22, 2008·The Cochrane Database of Systematic Reviews·D E BesselinkP O'Brien
Sep 12, 2019·Fertility Research and Practice·Palma G GubertMaria P Velez
Feb 9, 2011·Systems Biology in Reproductive Medicine·Luke Simon, Sheena E M Lewis
Jun 1, 2011·Research Synthesis Methods·Margaret SampsonChristine Urquhart
Feb 2, 2019·Environmental Science and Pollution Research International·Tiane Ferreira de CastroElton Pinto Colares
Oct 20, 2020·Fertility and Sterility·Rachel M WhynottRachel B Mejia
Sep 19, 2018·Chemosphere·Tiane Ferreira de CastroElton Pinto Colares
Jun 1, 2006·Current Opinion in Obstetrics & Gynecology

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