Performance of the UK Prospective Diabetes Study Risk Engine and the Framingham Risk Equations in Estimating Cardiovascular Disease in the EPIC- Norfolk Cohort.

Diabetes Care
R K SimmonsSimon J Griffin

Abstract

The purpose of this study was to examine the performance of the UK Prospective Diabetes Study (UKPDS) Risk Engine (version 3) and the Framingham risk equations (2008) in estimating cardiovascular disease (CVD) incidence in three populations: 1) individuals with known diabetes; 2) individuals with nondiabetic hyperglycemia, defined as A1C >or=6.0%; and 3) individuals with normoglycemia defined as A1C <6.0%. This was a population-based prospective cohort (European Prospective Investigation of Cancer-Norfolk). Participants aged 40-79 years recruited from U.K. general practices attended a health examination (1993-1998) and were followed for CVD events/death until April 2007. CVD risk estimates were calculated for 10,137 individuals. Over 10.1 years, there were 69 CVD events in the diabetes group (25.4%), 160 in the hyperglycemia group (17.7%), and 732 in the normoglycemia group (8.2%). Estimated CVD 10-year risk in the diabetes group was 33 and 37% using the UKPDS and Framingham equations, respectively. In the hyperglycemia group, estimated CVD risks were 31 and 22%, respectively, and for the normoglycemia group risks were 20 and 14%, respectively. There were no significant differences in the ability of the risk equations to discri...Continue Reading

References

Mar 11, 2000·BMJ : British Medical Journal·S RamachandranR H Neary
Jul 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·W W Yeo, K R Yeo
Nov 29, 2001·Clinical Science·R J StevensUNKNOWN United Kingdom Prospective Diabetes Study (UKPDS) Group
Jan 31, 2003·The New England Journal of Medicine·Peter GaedeOluf Pedersen
May 20, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·C CarrollT Dornan
Mar 31, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·P McEwanC J Currie
Jan 22, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·R J StevensR R Holman
Jun 2, 2006·BMJ : British Medical Journal·Vishnu Madhok, Tom Fahey
Jul 13, 2006·Archives of Internal Medicine·Donald M Lloyd-Jones, Lu Tian
May 12, 2007·The Review of Diabetic Studies : RDS·Tomas KoblasFrantisek Saudek
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel

❮ Previous
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Citations

Apr 9, 2013·Nutrition Research Reviews·R FallaizeJ A Lovegrove
Dec 4, 2010·Vascular Health and Risk Management·David ZakimM Dominik Alscher
Jun 13, 2012·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Morten CharlesSimon J Griffin
Jun 10, 2014·Indian Journal of Endocrinology and Metabolism·Partha Pratim ChakrabortySanjay Kalra
Aug 6, 2010·QJM : Monthly Journal of the Association of Physicians·F D R HobbsA L Catapano
Oct 23, 2012·Der Anaesthesist·G PestelM M Weber
Jan 15, 2013·Current Cardiology Reports·Pam R TaubRobert R Henry
Jul 20, 2011·Wiener medizinische Wochenschrift·Bernhard Föger
Dec 30, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ron Blankstein, Sharmila Dorbala
May 31, 2013·Journal of Medical Economics·Michael WillisJianming He
Sep 19, 2012·The American Journal of the Medical Sciences·Alireza EsteghamatiManouchehr Nakhjavani
Oct 1, 2009·Diabetes/metabolism Research and Reviews
Jun 16, 2012·International Journal of Clinical Practice·A S Wierzbicki
May 21, 2014·Journal of Diabetes Investigation·Naoto KatakamiIichiro Shimomura
Mar 12, 2015·Cardiovascular Therapeutics·Thilanga RuwanpathiranaChristopher M Reid
Jun 16, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·A SiebenhoferK Horvath
Aug 10, 2011·The American Journal of Cardiology·Shailesh NandishRobert Chilton
Aug 3, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E PellegriniN Carulli
Sep 18, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Libo TaoUNKNOWN ADDITION-Europe study team
Sep 23, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Phil McEwanDavid Grant

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