Performance of Vitek 2 in antimicrobial susceptibility testing of Pseudomonas aeruginosa isolates with different mechanisms of beta-lactam resistance.

Journal of Clinical Microbiology
Annarita MazzariolRoberta Fontana

Abstract

A total of 78 isolates of Pseudomonas aeruginosa grouped according to the phenotype for ceftazidime and imipenem susceptibility/resistance were used to assess the accuracy of the Vitek 2 system in antimicrobial susceptibility testing. Comparisons were made with a MIC gradient test for piperacillin-tazobactam, ceftazidime, aztreonam, imipenem, meropenem, gentamicin, and ciprofloxacin. For the total of 546 isolate-antimicrobial combinations tested, the category agreement was 83.6%, with 2.0, 1.6, and 12.8% very major, major, and minor errors, respectively. Vitek 2 accuracy was influenced differently by the mechanism responsible for resistance, and interpretation of the results in relation to phenotype could improve the performance of the system.

References

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Citations

Jul 8, 2011·Clinical Microbiology Reviews·Trevor Winstanley, Patrice Courvalin
Aug 11, 2015·Journal of Chemotherapy·Abed Zahedi BialvaeiMehdi Yousefi
Dec 1, 2017·The Journal of Antimicrobial Chemotherapy·Michael HombachErik C Böttger
Apr 18, 2018·Therapeutic Advances in Infectious Disease·Matthew SongRamy H Elshaboury
Sep 29, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Thomas GehringChristian Buechler

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