Performance status and trial site-level factors are associated with missing data in palliative care trials: An individual participant-level data analysis of 10 phase 3 trials.

Palliative Medicine
Jamilla A HussainDavid C Currow


Missing data compromise the internal and external validity of trial findings, however there is limited evidence on how best to reduce missing data in palliative care trials. To assess the association between participant and site level factors and missing data in palliative care trials. Individual participant-level data analysis of 10 phase 3 palliative care trials using multi-level cross-classified models. Participants with missing data at the previous time-point and poorer performance status were more likely to have missing data for the primary outcome and quality of life outcomes, at the primary follow-up point and end of follow-up. At the end of follow-up, the number of site randomisations and number of study site personnel were significantly associated with missing data. Trial duration and the number of research personnel explained most of the variance at the trial and site-level respectively, except for the primary outcome where the amount of data requested was most important at the trial-level. Variance at the trial level was more substantial than at the site level across models and considerable variance remained unexplained for all models except quality of life at the end of follow-up. Participants with a poorer performa...Continue Reading


Feb 9, 2010·BMJ : British Medical Journal·Richard D RileyGhada Abo-Zaid
Apr 29, 2015·JAMA : the Journal of the American Medical Association·Lesley A StewartUNKNOWN PRISMA-IPD Development Group
Aug 20, 2015·Research Synthesis Methods·Thomas P A DebrayUNKNOWN GetReal Methods Review Group
Feb 25, 2018·Trials·Shaun TreweekPaula R Williamson
Jul 6, 2020·Journal of Pain and Symptom Management·Abby R RosenbergJoyce P Yi-Frazier

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