Performing nondiagnostic research biopsies in irradiated tissue: a review of scientific, clinical, and ethical considerations.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Aaron P BrownDeborah Citrin

Abstract

Recent development of drugs that target specific pathways in tumors has increased scientific interest in studying drug effects on tumor tissue. As a result, biopsies have become an important part of many early-phase clinical trials. Performing nondiagnostic tumor biopsies raises technical and ethical concerns mostly related to the use of a potentially harmful procedure with no potential benefit to the patient. This issue is complicated by uncertainty about whether performing biopsies in irradiated fields adds significant risk. This article reviews the clinical, scientific, and ethical considerations involved in performing nondiagnostic tumor biopsies in competent adults for research purposes, with a focus on biopsies performed in the setting of therapeutic irradiation. Clinical trials that performed biopsies during or within 4 months of the completion of radiotherapy were identified with a literature review. Twenty-nine studies with 2,160 patients were identified. Sixteen of 29 studies reported adverse events (AEs) but did not report active evaluation for biopsy complications. Ten studies did not mention AEs within the study report. At least three studies actively evaluated patients for biopsy complications. Taking this into co...Continue Reading

References

Mar 1, 1992·Archives of Surgery·R D PeznerK H Luk
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·G MorstynJ Mitchell
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C DaughertyM Siegler
Apr 1, 1994·International Journal of Colorectal Disease·D M SedgwickA Ferguson
Jan 1, 1994·Clinics in Dermatology·R TokarekJ B Mitchell
Apr 2, 1993·International Journal of Radiation Oncology, Biology, Physics·W TesterE Hammond
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W TesterW Shipley
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W PistersM F Brennan
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L A KachnicW U Shipley
Jan 24, 1998·Journal of Thoracic Imaging·D AyarH Nath
Jul 29, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DelanianJ L Lefaix
Aug 26, 1998·Journal of Reconstructive Microsurgery·A GürlekG L Robb
Mar 27, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S BirkenhakeR Sauer
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·N HovdenakM Hauer-Jensen
Dec 6, 2000·JAMA : the Journal of the American Medical Association·J D Shelton
Jan 12, 2002·JAMA : the Journal of the American Medical Association·Karine MorinMonique A Spillman
Jun 14, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·James W Denham, Martin Hauer-Jensen
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre GérardGilles Freyer
Jun 28, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neal J MeropolKevin A Schulman
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Manish Agrawal, Ezekiel J Emanuel
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Ralph E Durand, Christina Aquino-Parsons
Oct 7, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Carlo CapirciCesare Polico
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Michael K M KamAnthony T C Chan
Jul 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Ferdinando CercielloIlja F Ciernik
Aug 4, 2005·ANZ Journal of Surgery·Jessica C C MeddAndre Lalak
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mohammed MohiuddinUNKNOWN Radiation Therapy Oncology Group Trial 0012
Mar 15, 2006·European Journal of Radiology·Noriyuki TomiyamaKozo Yamada

❮ Previous
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Citations

Oct 12, 2013·Breast Cancer Research and Treatment·Ines Vaz-LuisNancy U Lin
Aug 3, 2011·Nature Reviews. Clinical Oncology·Erin M OlsonEric P Winer
Sep 16, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C A Gomez-RocaJ-C Soria
Mar 16, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D S SeahNancy U Lin
Dec 13, 2012·Journal of the National Cancer Institute·Yaacov Richard LawrenceAdam P Dicker
May 19, 2010·Annual Review of Genomics and Human Genetics·Amy L McGuire, Laura M Beskow
Nov 7, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J OvermanAlda L Tam
Apr 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey PeppercornMonica M Bertagnolli
Aug 6, 2011·Journal of the American Podiatric Medical Association·Stephen J LongobardiE Hani Mansour
Oct 11, 2015·The Annals of Otology, Rhinology, and Laryngology·Gintas P KrisciunasSusan E Langmore
May 22, 2018·Clinical Journal of Oncology Nursing·Elizabeth AbrahamKarleen Habin
Nov 7, 2017·Asia-Pacific Journal of Clinical Oncology·Danielle H RobinsonDavinia Seah
Jun 12, 2018·Mass Spectrometry Reviews·Iwona BelczackaMaria Frantzi
Jul 26, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura A LevitMark J Ratain
Apr 5, 2017·Journal of the National Cancer Institute·Jonathan KimmelmanMark J Ratain
Dec 1, 2012·Clinical Trials : Journal of the Society for Clinical Trials·Joshua M JudgeCraig L Slingluff
Jul 30, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine M ParseghianMichael J Overman
Aug 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Georgina A Freeman, Jonathan Kimmelman
May 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C A Gomez-RocaJ-C Soria
Jul 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D S SeahNancy U Lin

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