Performing versus deferring coronary angioplasty based on functional evaluation of vessel stenosis by pressure measurements: a clinical outcome study

Journal of Cardiovascular Medicine
Edoardo VernaSalvatore Ivan Caico

Abstract

The present study aimed to prospectively evaluate whether application of the concept of fractional flow reserve (FFR) guides the immediate decision to perform or to defer coronary angioplasty in unselected consecutive patients with one or more angiographically intermediate (50-70%) stenoses and non-conclusive or lacking non-invasive testing. We studied 112 patients (81 males and 31 females, aged 31-81 years) including 71 multivessel disease patients (63%) and 30 patients (27%) with unstable symptoms. FFR was measured with the use of a pressure-wire after adenosine-induced hyperaemia and compared with quantitative coronary angiography in 171 stenoses. Coronary angioplasty was performed in the presence of an FFR < 0.75 and deferred if FFR was > or = 0.75. Cardiac events including death, myocardial infarction, recurrent angina or symptoms requiring repeated hospitalization and target vessel revascularization (TVR) were recorded during a median period of 34 months (interquartile range 9-54 months). Coronary angioplasty was deferred based on FFR results in 54 patients (group I). In the remaining 58 patients, angioplasty was performed in one or more stenoses that were significant by FFR and deferred in non-significant stenoses (group...Continue Reading

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Citations

Nov 11, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·James C BlankenshipUNKNOWN Society for Cardiovascular Angiography and Interventions
Jul 22, 2014·Clinical Cardiology·Anthony A BavryJohn W Petersen
Mar 22, 2014·Clinical Cardiology·Islam Y ElgendyAnthony A Bavry
Jun 29, 2011·Journal of Cardiovascular Medicine·Shipeng WeiXueqi Li
Nov 29, 2021·Journal of Cardiovascular Medicine·Marco ArenaAlberto Menozzi

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