PMID: 3747467Aug 1, 1986Paper

Perfused phantom models of microwave irradiated tissue

Journal of Biomechanical Engineering
J W BaishP S Ayyaswamy

Abstract

The theoretical basis, practical design considerations, and prototype testing of a perfused model suitable for simulation studies of microwave heated tissue are presented. A parallel tube heat exchanger configuration is used to simulate the internal convection effects of blood flow. The global thermal response of the phantom, on a scale of several tube spacings, is shown theoretically to be nearly identical to that predicted by Pennes' bioheat equation, which is known to give a reasonable representation of tissue under many conditions. A parametric study is provided for the relationships between the tube size, spacing and material properties and the simulated perfusion rate. A prototype with a physiologically reasonable perfusion rate was tested using a typical hyperthermia applicator. The measured thermal response of the phantom compares favorably with the numerical solution of the bioheat equation under the same irradiation conditions. This similarity sheds light on the unexpected success of the bioheat equation for modeling the thermal response of real tissue.

Citations

Feb 1, 1996·Journal of Biomechanical Engineering·H W HuangR B Roemer
Mar 1, 1990·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K D Paulsen, M P Ross
Jan 1, 1990·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J DelannoyD Delvalee
Apr 1, 1990·IEEE Transactions on Bio-medical Engineering·P J BenkeserS A Goss
Nov 1, 1990·IEEE Transactions on Bio-medical Engineering·J ZaerrK Hynynen
Jan 1, 1997·Bioelectromagnetics·P J RiuE R Adair
May 1, 1994·Physics in Medicine and Biology·J CrezeeG M van Leeuwen
Jul 9, 1998·Journal of Applied Physiology·D A Nelson
Mar 17, 2001·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A PayneR Roemer
Jun 7, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H Petra KokJohannes Crezee

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