Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial.

Trials
Mathilde M H PaulsAtticus H Hainsworth

Abstract

Cerebral small vessel disease is a common cause of vascular cognitive impairment in older people, with no licensed treatment. Cerebral blood flow is reduced in small vessel disease. Tadalafil is a widely prescribed phosphodiesterase-5 inhibitor that increases blood flow in other vascular territories. The aim of this trial is to test the hypothesis that tadalafil increases cerebral blood flow in older people with small vessel disease. Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS) is a phase II randomised double-blind crossover trial. In two visits, 7-30 days apart, participants undergo arterial spin labelling to measure cerebral blood flow and a battery of cognitive tests, pre- and post-dosing with oral tadalafil (20 mg) or placebo. 54 participants are required to detect a 15% increase in cerebral blood flow in subcortical white matter (p < 0.05, 90% power). Primary outcomes are cerebral blood flow in subcortical white matter and deep grey nuclei. Secondary outcomes are cortical grey matter cerebral blood flow and performance on cognitive tests (reaction time, information processing speed, digit span forwards and backwards, semantic fluency). Recruitment started on 4th Sept...Continue Reading

References

Nov 1, 1992·Stroke; a Journal of Cerebral Circulation·H YaoM Fujishima
Jan 7, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·M M EsiriJ H Morris
Sep 27, 2005·European Journal of Pharmacology·Christina KruuseJes Olesen
Feb 21, 2006·British Journal of Clinical Pharmacology·S Thomas ForgueMalcolm I Mitchell
Jul 28, 2006·British Journal of Clinical Pharmacology·S Thomas ForgueMalcolm I Mitchell
Nov 10, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Norbert SchuffMichael W Weiner
Dec 24, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Sean J CollobyJohn T O'Brien
Jul 11, 2012·Neuropharmacology·Carolina García-BarrosoAna García-Osta
Nov 23, 2012·ACS Chemical Neuroscience·Ana García-OstaRafael Franco
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Miguel D'haeseleerJacques De Keyser
Apr 2, 2014·Nature Reviews. Drug Discovery·Donald H MauriceVincent C Manganiello
Apr 10, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David C AlsopGreg Zaharchuk
May 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manya BernbaumShelagh B Coutts
Nov 26, 2015·Lancet·John T O'Brien, Alan Thomas
Jan 8, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eseosa T IghodaroPeter T Nelson
Mar 21, 2017·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Francesco ArbaUNKNOWN IST-3 Trial Collaborators

❮ Previous
Next ❯

Citations

Dec 20, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mathilde Mh PaulsJeremy D Isaacs
Sep 7, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Luis Hernandez-GarciaDouglas C Noll
Nov 23, 2019·Stroke; a Journal of Cerebral Circulation·Eric E Smith, Hugh S Markus
Oct 10, 2020·Brain Communications·Joakim ÖlmestigChristina Kruuse
Jul 7, 2020·Mechanisms of Ageing and Development·Valeriana CesariniSusanna Dolci

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02450253

Software Mentioned

PASTIS
SAS®

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.