Perfusion CT in colorectal cancer: comparison of perfusion parameters with tumor grade and microvessel density.

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Jin Woong KimHeoung Keun Kang

Abstract

The purpose of this study was to prospectively compare pre-operative computed tomography (CT) perfusion parameters with tumor grade from colorectal adenocarcinoma (CRC) and to correlate pre-operative CT perfusion parameters with microvessel density (MVD) to evaluate angiogenesis in CRC. Pre-operative perfusion CTs were performed with a 64-channel multidetector row CT in 27 patients (17 women and 10 men; age range 32-82 years) who were diagnosed with CRC involving the sigmoid and rectum between August 2006 and November 2007. All patients underwent surgery without pre-operative chemotherapy or radiation therapy. Dynamic perfusion CTs were performed for 65 seconds after intravenous injection of contrast medium (100 mL, 300 mg of iodine per mL, 5 mL/sec). Before surgery, blood flow (BF), blood volume, mean transit time (MTT), and permeability-surface area product were measured in the tumor. After surgery, one gastrointestinal pathologist evaluated tumor grade and performed immunohistochemical staining using CD 34 to determine MVD in each tumor. The Kruskal-Wallis test was used to compare CT perfusion parameters with tumor grade, and Pearson's correlation analysis was used to correlate CT perfusion parameters with MVD. In 27 patient...Continue Reading

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Citations

Jul 25, 2014·Radiology·Se Hyung KimJürgen K Willmann
Jan 18, 2014·The British Journal of Radiology·V Goh, R Glynne-Jones
May 4, 2016·Insights Into Imaging·Roberto García-FigueirasAna Álvarez-Castro
Jan 1, 2013·Diagnostics·Martin Lundsgaard HansenMichael Bachmann Nielsen
Jan 17, 2013·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Haejin KwonHak Jong Lee
Mar 23, 2017·World Journal of Gastroenterology : WJG·Xiao-Hua ChenJian-Bo Gao
Mar 20, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Dong Ho LeeJoon Koo Han

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Software Mentioned

Advantage Windows
Statistical Package for the Social Sciences ( SPSS

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