Perfusion maintains functional potential in denervated mimic muscles in early persistent facial paralysis which requires early microsurgical treatment - the histoanatomic basis of the extratemporal facial nerve trunk assessing axonal load in the context of possible nerve transfers

Clinical Hemorheology and Microcirculation
A KehrerV Mandlik

Abstract

Early persistent facial paralysis is characterized by intact muscles of facial expression through maintained perfusion but lacking nerve supply. In facial reanimation procedures aiming at restoration of facial tone and dynamics, neurotization through a donor nerve is performed. Critical for reanimating target muscles is axonal capacity of both donor and recipient nerves. In cases of complete paralysis, the proximal stump of the extratemporal facial nerve trunk may be selected as a recipient site for coaptation. To further clarify the histological basis of this facial reanimation procedure we conducted a human cadaver study examining macro and micro anatomical features of the facial nerve trunk including its axonal capacity in human cadavers. Axonal loads, morphology and morbidity of different donor nerves are discussed reviewing literature in context of nerve transfers. From 6/2015 to 9/2016 in a group of 53 fresh frozen cadavers a total of 106 facial halves were dissected. Biopsies of the extratemporal facial nerve trunk (FN) were obtained at 1 cm distal to the stylomastoid foramen. After histological processing and digitalization of 99 specimens available, 97 were selected eligible for fascicle counts and 87 fulfilled quality...Continue Reading

References

Jul 1, 1992·Journal of Neurosurgery·M J Ebersold, L M Quast
Sep 1, 1989·The Annals of Otology, Rhinology, and Laryngology·M Fujii, N Goto
May 1, 1980·Journal of Neurosurgery·L G Kempe
May 1, 1995·Journal of Reconstructive Microsurgery·S E Mackinnon, A L Dellon
Nov 4, 1998·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·E Brenner, T Schoeller
Aug 5, 1999·Journal of Neurosurgery·K AsaokaT Fukushima
Feb 11, 2000·Journal of Reconstructive Microsurgery·B MersaJ K Terzis
Jun 6, 2000·Plastic and Reconstructive Surgery·P S CedernaW M Kuzon
Oct 6, 2001·American Journal of Surgery·J J ManniR J Stokroos
Mar 9, 2002·Plastic and Reconstructive Surgery·Hideo NakajimaSadakazu Aiso
Apr 30, 2005·Plastic and Reconstructive Surgery·Guillaume CaptierFrançois Seignarbieux
Sep 7, 2005·Postgraduate Medical Journal·D H Harrison
Oct 10, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·C J CoombsM K Leung
Mar 26, 2009·Plastic and Reconstructive Surgery·Julia K Terzis, Kallirroi Tzafetta
Mar 26, 2009·Plastic and Reconstructive Surgery·Julia K Terzis, Fatima S Olivares
Jul 1, 2007·The Canadian Journal of Plastic Surgery = Journal Canadien De Chirurgie Plastique·Aaron M KosinsGarrett A Wirth
Feb 1, 2004·Seminars in Plastic Surgery·Michael Klebuc, Saleh M Shenaq
Jul 3, 2010·Plastic and Reconstructive Surgery·Julia K Terzis, Dimitrios Karypidis
Apr 30, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Alejandro RivasHoward W Francis
May 3, 2011·Plastic and Reconstructive Surgery·Michael J A Klebuc
Oct 14, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Gregory H BorschelAlbert S Woo
Nov 16, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yoichiro KondoMasahiro Itoh
Apr 24, 2012·Okajimas Folia Anatomica Japonica·Koji IshibeKazuyuki Shimada
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Jul 31, 2013·Diagnostic and Interventional Imaging·F ToulgoatH A Desal
Nov 26, 2013·F1000prime Reports·Kofi Boahene
Oct 3, 2014·BioMed Research International·D Grinsell, C P Keating
Apr 1, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Nobutaka Yoshioka, Shinsuke Tominaga
May 29, 2015·Plastic and Reconstructive Surgery·Ryan M GarciaJeffrey R Marcus
Jul 21, 2015·The British Journal of Oral & Maxillofacial Surgery·F Biglioli
Sep 24, 2015·Neurosurgery·Wilson Z RayLynda Yang
Feb 19, 2016·Experimental and Therapeutic Medicine·Shuo LiHai-Dong Liang
Sep 28, 2017·The Journal of Craniofacial Surgery·Alexánder Cárdenas-MejíaTzilacatzin Hernández
Nov 1, 2017·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Hyung-Jin LeeHee-Jin Kim
Dec 10, 2017·JAMA Facial Plastic Surgery·Alexander W MurpheySamuel L Oyer
Jan 10, 2018·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Federico BiglioliChiarella Sforza
Jan 13, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·A KehrerV Mandlik

❮ Previous
Next ❯

Citations

Jan 22, 2019·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Andreas KehrerVeronika Mandlik
Sep 25, 2020·Archives of Plastic Surgery·Laura SommerauerAndreas Kehrer

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
dissection
biopsy

Software Mentioned

ImageJ
SPSS
Zeiss AxioVision Microscope Software
Fiji
Axio Vision

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.